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Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR

2022Journal article Open access
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dc.contributor.authorSantos, Torcato
dc.contributor.authorWarren, Lewis H.
dc.contributor.authorSantos, Ana Rita B. M.
dc.contributor.authorMarques, Inês Pereira
dc.contributor.authorKubach, Sophie
dc.contributor.authorMendes, Luís G.
dc.contributor.authorSisternes, Luís de
dc.contributor.authorMadeira, Maria H.
dc.contributor.authorDurbin, Mary
dc.contributor.authorCunha-Vaz, José G.
dc.date.accessioned2022-05-23T09:50:57Z
dc.date.available2022-05-23T09:50:57Z
dc.date.issued2022
dc.description.abstractTo test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. 105 patients with diabetes, either without retinopathy or with different degrees of retinopathy (NPDR up to ETDRS grade 53), were prospectively evaluated using swept-source OCTA (SS-OCTA, PlexElite, Carl Zeiss Meditec) with 15×9 mm and 3×3 mm angiography protocols. Seven-field photographs of the fundus were obtained for ETDRS staging. Eyes from age-matched healthy subjects were also imaged as control. In eyes of patients with type 2 diabetes without retinopathy or ETDRS levels 20 and 35, retinal capillary closure was in the macular area, with predominant alterations in the parafoveal retinal circulation (inner ring). Retinal capillary closure in ETDRS stages 43-53 becomes predominant in the retinal midperiphery with vessel density average values of 25.2±7.9 (p=0.001) in ETDRS 43 and 23.5±3.4 (p=0.001) in ETDRS 47-53, when evaluating extended areas of 15×9 protocol. Combination of acquisition protocols 3×3 mm and 15×9 mm, using SS-OCTA, allows discrimination between eyes with mild NPDR (ETDRS 10, 20, 35) and eyes with moderate-to-severe NPDR (ETDRS grades 43-53). Retinal capillary closure, quantified by SS-OCTA, can identify NPDR severity progression. It is located mainly in the perifoveal retinal capillary circulation in the initial stages of NPDR, whereas the retinal midperiphery is predominantly affected in moderate-to-severe NPDR.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, T., Warren, L. H., Santos, A. R., Marques, I. P., Kubach, S., Mendes, L. G., Sisternes, L., Madeira, M. H., Durbin, M., & Cunha-Vaz, J. G. (2022). Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR. The British journal of ophthalmology, 106(5), 712–718. https://doi.org/10.1136/bjophthalmol-2020-317890pt_PT
dc.identifier.doi10.1136/bjophthalmol-2020-317890pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/20555
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJpt_PT
dc.relation.publisherversionhttps://bjo.bmj.com/content/106/5/712.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectDiagnostic tests/Investigationpt_PT
dc.subjectImagingpt_PT
dc.subjectRetinapt_PT
dc.titleSwept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDRpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage718pt_PT
oaire.citation.startPage712pt_PT
oaire.citation.titleBritish Journal of Ophthalmologypt_PT
oaire.citation.volume106pt_PT
person.familyNameB M Santos
person.givenNameAna Rita
person.identifier.ciencia-id291A-15C5-9C96
person.identifier.orcid0000-0003-3761-3292
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcf304315-48a2-4bae-a1d5-61a4c8e45274
relation.isAuthorOfPublication.latestForDiscoverycf304315-48a2-4bae-a1d5-61a4c8e45274

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