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The role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report

2016Journal article Open access
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dc.contributor.authorSantos, Marlene
dc.contributor.authorCarvalho, Serafim
dc.contributor.authorLima, Luís
dc.contributor.authorMota-Pereira, Jorge
dc.contributor.authorPimentel, Paulo
dc.contributor.authorMaia, Dulce
dc.contributor.authorCorreia, Diana
dc.contributor.authorGomes, Sofia
dc.contributor.authorCruz, Agostinho
dc.contributor.authorMedeiros, Rui
dc.date.accessioned2017-01-20T14:26:30Z
dc.date.available2017-01-20T14:26:30Z
dc.date.issued2016
dc.description.abstractRecent studies suggest that immune activation and cytokines, such as IL-18, are involved in depression. IL-18 is expressed in brain and is increased in patients with moderate to severe depression. In this study we aim to evaluate the role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes, specifically relapse and treatment resistant depression (TRD). We genotyped the referred polymorphisms in a subset of 80 MDD patients followed at Hospital Magalhães Lemos, Portugal, within a period of 27 months. Patients carrying IL18-607 CA or AA genotypes were significantly more prone to relapse after AD treatment and present a significantly lower time to relapse than patients carrying CC genotype. Similarly, patients carrying IL18-137 GC or CC genotypes have a significantly higher risk of relapse and display relapse significantly earlier than the ones carrying GG genotype. Due to the low number of IL18-607 CC and IL18-137 GG in the relapse subgroup (n = 3 and n = 5, respectively), results were validated by bootstrapping analysis, and remained significant. No association was found between the evaluated genetic polymorphisms and TRD. IL18 peripheral mRNA levels were upregulated in IL18-607 CA or AA carriers. This preliminary report indicates that IL18-607C > A and IL18-137G > C genetic polymorphisms seem to influence depression relapse after antidepressant treatment in our subset of depressed patients, and may possibly contribute to the disregulated IL-18 levels found in patients with depression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, M., Carvalho, S., Lima, L., Mota-Pereira, J., Pimentel, P., Maia, D., Correia, D., Gomes, S., Cruz, A., & Medeiros, R. (2016). The role of IL18-607C>A and IL18-137G>C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report. Neuroscience Letters, 622, 107–112. https://doi.org/10.1016/j.neulet.2016.03.026
dc.identifier.doi10.1016/j.neulet.2016.03.026pt_PT
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/10400.22/9332
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0304394016301562pt_PT
dc.subjectCytokinespt_PT
dc.subjectAntidepressantspt_PT
dc.subjectIL18pt_PT
dc.subjectRelapsept_PT
dc.subjectGenetic polymorphismspt_PT
dc.titleThe role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary reportpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage112pt_PT
oaire.citation.startPage107pt_PT
oaire.citation.titleNeuroscience Letterspt_PT
oaire.citation.volume622pt_PT
person.familyNameSantos
person.familyNameOliveira Lima
person.familyNameCruz
person.givenNameMarlene
person.givenNameLuís Carlos
person.givenNameAgostinho
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.ciencia-id9F16-0E29-D9FC
person.identifier.orcid0000-0001-5020-5942
person.identifier.orcid0000-0001-8152-9237
person.identifier.orcid0000-0002-1157-8196
person.identifier.scopus-author-id57110502000
person.identifier.scopus-author-id23501978900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublicationc6b00c1f-f4c9-4f4f-b291-17cf30b1e1f8
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication.latestForDiscoveryd7ec3c5d-b3e0-4e34-8e24-4d1588876120

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