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Tracing the path between mushrooms and Alzheimer’s Disease—a literature review

2023-07-24Journal article Open access
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dc.contributor.authorSilva, Ana Margarida
dc.contributor.authorPreto, Marco
dc.contributor.authorGrosso, Clara
dc.contributor.authorVieira, Mónica
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorVasconcelos, Vitor
dc.contributor.authorReis, Mariana
dc.contributor.authorBarros, Lillian
dc.contributor.authorMartins, Rosario
dc.date.accessioned2023-09-07T15:56:00Z
dc.date.available2023-09-07T15:56:00Z
dc.date.issued2023-07-24
dc.description.abstractAlzheimer’s disease (AD) is well-known among neurodegenerative diseases for the decline of cognitive functions, making overall daily tasks difficult or impossible. The disease prevails as the most common form of dementia and remains without a well-defined etiology. Being considered a disease of multifactorial origin, current targeted treatments have only managed to reduce or control symptoms, and to date, only two drugs are close to being able to halt its progression. For decades, natural compounds produced by living organisms have been at the forefront of research for new therapies. Mushrooms, which are well-known for their nutritional and medicinal properties, have also been studied for their potential use in the treatment of AD. Natural products derived from mushrooms have shown to be beneficial in several AD-related mechanisms, including the inhibition of acetylcholinesterase (AChE) and β-secretase (BACE 1); the prevention of amyloid beta (Aβ) aggregation and neurotoxicity; and the prevention of Tau expression and aggregation, as well as antioxidant and anti-inflammatory potential. Several studies in the literature relate mushrooms to neurodegenerative diseases. However, to the best of our knowledge, there is no publication that summarizes only AD data. In this context, this review aims to link the therapeutic potential of mushrooms to AD by compiling the anti-AD potential of different mushroom extracts or isolated compounds, targeting known AD-related mechanisms.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A. M., Preto, M., Grosso, C., Vieira, M., Delerue-Matos, C., Vasconcelos, V., Reis, M., Barros, L., & Martins, R. (2023). Tracing the Path between Mushrooms and Alzheimer’s Disease—A Literature Review. Molecules, 28(14), 5614. https://doi.org/10.3390/molecules28145614pt_PT
dc.identifier.doi10.3390/molecules28145614pt_PT
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.22/23473
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/28/14/5614pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMushroomspt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectNatural productspt_PT
dc.subjectTherapypt_PT
dc.titleTracing the path between mushrooms and Alzheimer’s Disease—a literature reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage28pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume28 (14)pt_PT
person.familyNameSilva
person.familyNameAlmeida Vieira
person.familyNameMartins
person.givenNameAna Margarida
person.givenNameMónica Andreia
person.givenNameRosario
person.identifier.ciencia-id9712-AF1E-C8D1
person.identifier.ciencia-idA01E-9178-9B48
person.identifier.ciencia-idA919-DB40-EF10
person.identifier.orcid0000-0002-9582-3178
person.identifier.orcid0000-0002-8687-4811
person.identifier.orcid0000-0002-9882-4651
person.identifier.scopus-author-id21834368700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication76fafad5-3c94-44d5-bc2a-9814e0ecb940
relation.isAuthorOfPublication861e9c68-4ecc-4be1-a794-852343368e9a
relation.isAuthorOfPublication82a7c349-c88e-450f-adc7-3331d69149cf
relation.isAuthorOfPublication.latestForDiscovery82a7c349-c88e-450f-adc7-3331d69149cf

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