Publication
Micro-QuEChERS extraction coupled to GC–MS for a fast determination of Bisphenol A in human urine
| dc.contributor.author | Correia-Sá, Luísa | |
| dc.contributor.author | Norberto, Sónia | |
| dc.contributor.author | Delerue-Matos, Cristina | |
| dc.contributor.author | Calhau, Conceição | |
| dc.contributor.author | Domingues, Valentina F. | |
| dc.date.accessioned | 2019-10-29T15:35:49Z | |
| dc.date.available | 2019-10-29T15:35:49Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Bisphenol A (BPA) is considered an endocrine disruptor and public concern over BPA exposure has been raised. Several studies have assessed human exposure to this plasticizer, confirming its ubiquitous presence and highlighting children as a public of special concern. A simple, efficient, cheap and green analytical procedure is reported within this paper. This paper reports, for the first time, the development of a modified Micro-QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method coupled to gas chromatography-mass spectrometry (GC-MS) as a new strategy for the efficient extraction and determination of Bisphenol A in human urine samples. Several parameters that are known to influence extraction were optimized. Good linearity was achieved at the studied concentration range (1-50μg/L), with a correlation coefficient (R2) of 0.998. The optimized method proved to be accurate (≥74% recovery), reproducible (<11% relative standard deviation) and sensitive for BPA determination (detection limit of 0.13μg/L and quantification limit of 0.43μg/L). The analytical procedure was applied to the analyses of 12 urine samples collected from children living in the North/Center region of Portugal. BPA was detected in all the analyzed samples in concentrations ranging from 1.5μg/L to 48.9μg/L. The proposed methodology is suitable for the determination of BPA in urine samples in the framework of biomonitoring studies and bioanalytical analyses, applying GC-MS detection. | pt_PT |
| dc.description.sponsorship | Luísa Correia-Sá is grateful to FCT by the grant (SFRH/BD/87019/2012), financed by POCH, subsidized by Fundo Social Europeu and Ministério da Ciência, Tecnologia e Ensino Superior. The authors are thankful to the project Qualidade e Segurança Alimentar – uma abordagem (nano) tecnológica, reference NORTE-01-0145-FEDER-000011. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.jchromb.2017.10.060 | |
| dc.identifier.issn | 1570-0232 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/14763 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation | ENDOCRINE DISRUPTORS BIOMONITORING IN CHILDREN: EXPOSURE ASSESSMENT AND OBESITY INCIDENCE | |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1570023217312242?via%3Dihub | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Bisphenol A | pt_PT |
| dc.subject | Micro-QuEChERS | pt_PT |
| dc.subject | Human urine | pt_PT |
| dc.subject | GC–MS | pt_PT |
| dc.subject | Children | pt_PT |
| dc.title | Micro-QuEChERS extraction coupled to GC–MS for a fast determination of Bisphenol A in human urine | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | ENDOCRINE DISRUPTORS BIOMONITORING IN CHILDREN: EXPOSURE ASSESSMENT AND OBESITY INCIDENCE | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87019%2F2012/PT | |
| oaire.citation.endPage | 16 | pt_PT |
| oaire.citation.startPage | 9 | pt_PT |
| oaire.citation.title | Journal of Chromatography B | pt_PT |
| oaire.citation.volume | 1072 | pt_PT |
| person.familyName | Correia-Sá | |
| person.familyName | Delerue-Matos | |
| person.familyName | Domingues | |
| person.givenName | Luísa | |
| person.givenName | Cristina | |
| person.givenName | Valentina Maria Fernandes | |
| person.identifier.ciencia-id | 231E-E28E-94D9 | |
| person.identifier.ciencia-id | 9A1A-43FB-5C27 | |
| person.identifier.ciencia-id | 4E16-791D-6664 | |
| person.identifier.orcid | 0000-0003-1135-0260 | |
| person.identifier.orcid | 0000-0002-3924-776X | |
| person.identifier.orcid | 0000-0003-3472-849X | |
| person.identifier.rid | Q-5259-2018 | |
| person.identifier.rid | D-4990-2013 | |
| person.identifier.scopus-author-id | 55070939500 | |
| person.identifier.scopus-author-id | 6603741848 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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