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Nephrotoxicity effects of the wood preservative chromium copper arsenate on mice: histopathological and quantitative approaches
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Orientador(es)
Resumo(s)
Chromium copper arsenate(CCA)was used for the protection of wood building material suntil the restriction by
EPA in2002.
During a short period of time 14–24h,a comparative nephrotoxicity study was performed regarding the effects of
CCA and its compounds per se. Histopathological and histochemical features were correlated with the concentration
of the total arsenic and chromium in mice kidney.
Animals were subcutaneously injected with CCA(7.2mg/kg arsenic and 10.2mg/kg chromium per body weight),
CrO3 (10.2 mg/kg),As2O5 (7.2 mg/kg)andNaCl(0.9%) per se.
The histopathological examination of the renal sections evidenced acute tubular necrosis in the groups of animals
exposed to CCA(in both periods of time).
Although the same contents of pentavalent arsenic and hexavalent chromium were injected in treated animals with
CCA and with the prepared solutions of As2O5 and CrO3, the arsenic concentration on kidneys of CCA-exposed
animals was much higher than those in animals exposed to As2O5 (32- and28-fold higher at 14 and 24h,respectively).
However,the elimination of chromium seems to occur similarly in the kidneys of animals treated with CCA and CrO3
per se. Interactions among the components of CCA result in a marked decrease of the ability of kidney to eliminate
simultaneously both analytes.The nephrotoxicity of CCA was higher than its components per se, evidencing a possible
synergetic effect.
Descrição
Palavras-chave
Chromium copper arsenate Kidney Acute tubular necrosis Histochemistry Atomic absorption spectrometry
Contexto Educativo
Citação
Editora
Elsevier