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Peptide conjugates for the topical treatment of infected wounds

2023-07Conference object Open access
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dc.contributor.authorGomes, Ana
dc.contributor.authorFernandes, Iva
dc.contributor.authorBessa, Lucinda
dc.contributor.authorFerreira, Mariana
dc.contributor.authorMaciel, Joana
dc.contributor.authorPlácido, Alexandra
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorLeal, Ermelindo
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorGameiro, Paula
dc.contributor.authorCarvalho, Eugénia
dc.contributor.authorGomes, Paula
dc.date.accessioned2024-05-29T13:40:23Z
dc.date.available2024-05-29T13:40:23Z
dc.date.issued2023-07
dc.description.abstractDue to widespread multidrug-resistant (MDR) microbes, efficient treatments for infected wounds are being exhausted.1 The symptoms of wound infection are consistent with local polymicrobial biofilms, which are difficult to eliminate and delay the healing process. The current standard of care requires oral antibiotics and other measures, often complex and distressing (e.g., amputations). A perfect treatment should promote both antimicrobial protection and fast tissue regeneration, to improve the inefficient healing in elderly people affected with, e.g., diabetes or venous/arterial insufficiency. 2 Considering the above, we advance peptide conjugates as potential active pharmaceutical ingredients for topical formulations to tackle skin infections. Such conjugates are anticipated to concomitantly display antimicrobial and anti-biofilm action along with fast healing through, e.g., collagenesis-inducing effects. Promising results were obtained with chimeric peptides combining a de novo designed antimicrobial peptide sequence 3 with a cosmetic peptide, used as anti-aging, with ability to induce collagen production.4 The best constructs exhibited: (i) antibacterial and anti-biofilm activity against Gram-positive and Gram-negative bacteria, including MDR clinical isolates; (iii) improved action against S. aureus (prevalent pathogen in chronically-infected wounds) in simulated wound fluid; and (v) antifungal activity. 5 The replacement of the antimicrobial peptide by an ionic liquid afforded a new conjugate, a peptide-ionic liquid construct, with broadspectrum antibacterial activity, antifungal action, and collagen-inducing effect. These results will be shown alongside the most recent findings that provide deeper insight into the mode of action of the best conjugates.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, A., Fernandes, I., Bessa, L., Ferreira, M., Maciel, J., Plácido, A., Teixeira, C., Leal, E., Ferraz, R., Gameiro, P., Carvalho, E., & Gomes, P. (2023). Peptide conjugates for the topical treatment of infected wounds. Em D. C. G. A. Pinto, A. M. S. Silva, & J. Rocha (Eds.), Abstract book of the XVIII National Meeting of the Portuguese Society of Chemistry (p. 268). Sociedade Portuguesa de Química da Universidade de Aveiro.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/25592
dc.language.isoengpt_PT
dc.publisherSociedade Portuguesa de Química da Universidade de Aveiropt_PT
dc.relationThis work was financed by FCT-Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação through the financing support to LAQV-REQUIMTE (UIDB/50006/2020 and UIDP/50006/2020).pt_PT
dc.relation.publisherversionhttps://bitok.datastore.pt/scimeet-prod/cms/xxviiienspq.events.chemistry.pt/d2911da4-0900-4bc5-b9cc-d3090c18c545/LivrodeResumos.pdfpt_PT
dc.subjectMDRpt_PT
dc.subjectPolymicrobial biofilmspt_PT
dc.titlePeptide conjugates for the topical treatment of infected woundspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceAveiropt_PT
oaire.citation.startPage268pt_PT
oaire.citation.titleAbstract book of the XVIII National Meeting of the Portuguese Society of Chemistrypt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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