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Lichen extracts containing volatile compounds induce oxidative stress and modulate the growth of Microcystis aeruginosa and Chlorella sorokiniana

2026-05-26Artigo de investigação Acesso aberto
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dc.contributor.authorEssadki, Yasser
dc.contributor.authorDarrag, El Mehdi
dc.contributor.authorZerrifi, Soukaina El Amrani
dc.contributor.authorHaida, Mohamed
dc.contributor.authorKrimech, Aafaf
dc.contributor.authorMartins, Rosário
dc.contributor.authorCampos, Alexandre
dc.contributor.authorVasconcelos, Vitor
dc.contributor.authorBouaïcha, Noureddine
dc.contributor.authorBaçaoui, Abdelaziz
dc.contributor.authorMeddich, Abdelilah
dc.contributor.authorOudra, Brahim
dc.contributor.authorTazart, Zakaria
dc.contributor.authorEl Khallouf, Fatima
dc.contributor.authorMartins, Rosario
dc.date.accessioned2026-05-27T08:23:38Z
dc.date.available2026-05-27T08:23:38Z
dc.date.issued2026-05-26
dc.description.abstractThis study evaluates volatile extracts (HE1 and HE2) from the lichen Pseudevernia furfuracea as eco-friendly agents to control algal proliferation, specifically targeting the cyanobacterium Microcystis aeruginosa and the green microalga Chlorella sorokiniana. Both extracts exhibited potent anti-microalgal activity against the two species with a minimum inhibitory concentration (MIC) ranging from 375 to 750 µg/mL. Furthermore, both extracts reduced cell density by more than 98% after eight days of treatment. Chlorophyll a and protein levels decreased significantly (>80%) in both species, indicating suppression of pigment synthesis. However, their physiological responses were distinct: M. aeruginosa underwent early acute oxidative stress and severe membrane damage, while C. sorokiniana exhibited delayed oxidative activation and a negative growth rate, suggesting non-lytic metabolic inhibition. An in silico study by molecular docking of the most abundant compounds identified in these volatile extracts, such as terpenoids (abietatriene, δ-cadinene) and a phenolic compound (atraric acid), showed that these compounds interact with vital cellular targets in M. aeruginosa and C. sorokiniana and likely contribute to the effects observed in these two species. Predictive toxicity by applying the ADMET framework confirmed the favorable bioavailability and low acute toxicity of these volatile compounds. Therefore, P. furfuracea volatiles are promising, species-specific, and environmentally safe candidates for mitigating aquatic algal proliferation through targeted oxidative and metabolic interference.eng
dc.description.sponsorshipTOXICROP project financed by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 823860.
dc.identifier.citationEssadki, Y., Darrag, E. M., Zerrifi, S. E. A., Haida, M., Krimech, A., Martins, R., Campos, A., Vasconcelos, V., Bouaïcha, N., Baçaoui, A., Meddich, A., Oudra, B., Tazart, Z., & Khalloufi, F. E. (2026). Lichen extracts containing volatile compounds induce oxidative stress and modulate the growth of Microcystis aeruginosa and Chlorella sorokiniana. International Journal of Molecular Sciences, 27(11), 1–32. https://doi.org/10.3390/ijms27114790
dc.identifier.doi10.3390/ijms27114790
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.22/32431
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://www.mdpi.com/1422-0067/27/11/4790
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPseudevernia furfuracea
dc.subjectVolatile organic compounds (VOCs)
dc.subjectAnti-cyanobacterial activity
dc.subjectAnti-microalgae
dc.subjectOxidative stress
dc.subjectAlgal proliferation
dc.subjectMolecular docking
dc.titleLichen extracts containing volatile compounds induce oxidative stress and modulate the growth of Microcystis aeruginosa and Chlorella sorokinianaeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage32
oaire.citation.issue11
oaire.citation.startPage1
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.citation.volume27
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa
person.familyNameMartins
person.givenNameRosario
person.identifier.ciencia-idA919-DB40-EF10
person.identifier.orcid0000-0002-9882-4651
person.identifier.scopus-author-id21834368700
relation.isAuthorOfPublication82a7c349-c88e-450f-adc7-3331d69149cf
relation.isAuthorOfPublication.latestForDiscovery82a7c349-c88e-450f-adc7-3331d69149cf

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