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Phthalates and type 1 diabetes: is there any link?

2018-04Journal article Open access
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dc.contributor.authorCastro-Correia, Cíntia
dc.contributor.authorCorreia-Sá, Luísa
dc.contributor.authorNorberto, Sónia
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorDomingues, Valentina
dc.contributor.authorCosta-Santos, Cristina
dc.contributor.authorFontoura, Manuel
dc.contributor.authorCalhau, Conceição
dc.date.accessioned2019-09-13T09:43:31Z
dc.date.available2019-09-13T09:43:31Z
dc.date.issued2018-04
dc.description.abstractPhthalates are a group of chemical compounds used as plasticizers in the manufacture of plastic materials. They can be present in many commonly used products. There seems to be a relationship between exposure to phthalates and the occurrence of metabolic dysfunctions, such as a decrease in glucose tolerance, oxidative stress, loss of beta cells, and a decrease in insulin synthesis. As beta cells play a key role in the onset of type 1 diabetes mellitus (T1DM), we sought to investigate the relationship between exposure to phthalates and the diagnosis of T1DM in prepubertal children. Design concentrations of phthalate metabolites were compared in the urine of a population of prepubertal children with new-onset diabetes, patients with T1DM diagnosed more than 6 months previously, and healthy control children. Although the concentrations of DBP and DiBP metabolites were statistically identical in the new-onset diabetes, diabetes, and control groups, there was a clear trend for higher levels of DiBP metabolites in the children with new-onset diabetes. In our sample, there was a trend for higher levels of DiBP metabolites in children with new-onset diabetes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCastro-Correia, C., Correia-Sá, L., Norberto, S. et al. Environ Sci Pollut Res (2018) 25: 17915. https://doi.org/10.1007/s11356-018-1997-zpt_PT
dc.identifier.doi10.1007/s11356-018-1997-z
dc.identifier.issn1614-7499
dc.identifier.urihttp://hdl.handle.net/10400.22/14596
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs11356-018-1997-zpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAdolescentpt_PT
dc.subjectChildpt_PT
dc.subjectDiabetes Mellitus, Type 1pt_PT
dc.subjectHumanspt_PT
dc.subjectInsulin-Secreting Cellspt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectPhthalic Acidspt_PT
dc.subjectPlasticizerspt_PT
dc.subjectPlasticspt_PT
dc.subjectPhthalatespt_PT
dc.subjectType 1 diabetespt_PT
dc.titlePhthalates and type 1 diabetes: is there any link?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage17919pt_PT
oaire.citation.issue18pt_PT
oaire.citation.startPage17915pt_PT
oaire.citation.titleEnvironmental Science and Pollution Researchpt_PT
oaire.citation.volume25pt_PT
person.familyNameCorreia-Sá
person.familyNameDelerue-Matos
person.familyNameDomingues
person.givenNameLuísa
person.givenNameCristina
person.givenNameValentina Maria Fernandes
person.identifier.ciencia-id231E-E28E-94D9
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-id4E16-791D-6664
person.identifier.orcid0000-0003-1135-0260
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0003-3472-849X
person.identifier.ridQ-5259-2018
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id55070939500
person.identifier.scopus-author-id6603741848
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione5b2f84a-6e8c-49ce-a7ee-d9dcccf2fb6e
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublicationbe653ab6-34ec-4329-972a-eee990a7ec66
relation.isAuthorOfPublication.latestForDiscoverye5b2f84a-6e8c-49ce-a7ee-d9dcccf2fb6e

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