Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells

Freitas, Sara; Martins, Rosario; Costa, Margarida; Leão, Pedro; Vitorino, Rui; Vasconcelos, Vitor; Urbatzka, Ralph

http://hdl.handle.net/10400.22/9269

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Abstract(s)

Hierridin B was isolated from a marine cyanobacterium Cyanobium sp. strain and induced cytotoxicity selectively in HT-29 adenocarcinoma cells. The underlying molecular mechanism was not yet elucidated.

Keywords

Natural products Bioactive compounds Anticancer drugs Colon cancer cells Marine cyanobacteria Mitochondria Vdac1 Cell cycle Proteomics High content analysis