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Electrochemical Biosensing in Cancer Diagnostics and Follow-up

2018Journal article Open access
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dc.contributor.authorFreitas, Maria
dc.contributor.authorNouws, Henri
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2019-10-29T16:29:38Z
dc.date.available2019-10-29T16:29:38Z
dc.date.issued2018
dc.description.abstractIn cancer, screening and early detection are critical for the success of the patient's treatment and to increase the survival rate. The development of analytical tools for non‐invasive detection, through the analysis of cancer biomarkers, is imperative for disease diagnosis, treatment and follow‐up. Tumour biomarkers refer to substances or processes that, in clinical settings, are indicative of the presence of cancer in the body. These biomarkers can be detected using biosensors, that, because of their fast, accurate and point of care applicability, are prominent alternatives to the traditional methods. Moreover, the constant innovations in the biosensing field improve the determination of normal and/or elevated levels of tumour biomarkers in patients’ biological fluids (such as serum, plasma, whole blood, urine, etc.). Although several biomarkers (DNA, RNA, proteins, cells) are known, the detection of proteins and circulating tumour cells (CTCs) are the most commonly reported due to their approval as tumour biomarkers by the specialized entities and commonly accepted for diagnosis by medical and clinical teams. Therefore, electrochemical immunosensors and cytosensors are vastly described in this review, because of their fast, simple and accurate detection, the low sample volumes required, and the excellent limits of detection obtained. The biosensing strategies reported for the six most commonly diagnosed cancers (lung, breast, colorectal, prostate, liver and stomach) are summarized and the distinct phases of the sensors’ constructions (surface modification, antibody immobilization, immunochemical interactions, detection approach) and applications are discussed.pt_PT
dc.description.sponsorshipMaria Freitas is grateful to FCT‐Fundação para a Ciência e a Tecnologia for her PhD grant (SFRH/BD/111942/2015), financed by POPH‐QREN‐Tipologia 4.1‐Formaçãpo Avançada, subsidized by Fundo Social Europeu and Ministério da Ciência, Tecnologia e Ensino Superior. This work received financial support from the European Union (FEDER funds through COMPETE) and National Funds (FCT) through project UID/QUI/50006/2013.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/elan.201800193
dc.identifier.urihttp://hdl.handle.net/10400.22/14765
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley-VCH Verlagpt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/elan.201800193pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCancer biomarkerpt_PT
dc.subjectElectrochemical biosensingpt_PT
dc.subjectImmunosensorpt_PT
dc.subjectCytosensorpt_PT
dc.subjectNanomaterialpt_PT
dc.titleElectrochemical Biosensing in Cancer Diagnostics and Follow-uppt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage1603pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1584pt_PT
oaire.citation.titleElectroanalysispt_PT
oaire.citation.volume30pt_PT
oaire.fundingStream5876
person.familyNameNouws
person.familyNameDelerue-Matos
person.givenNameHendrikus
person.givenNameCristina
person.identifier1046746
person.identifier.ciencia-idBC12-319B-037F
person.identifier.ciencia-id9B1A-9CED-6EE3
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-0628-2753
person.identifier.orcid0000-0002-1472-8866
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-5249-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id7801450247
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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