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Essential trace elements status in portuguese pregnant women and their association with maternal and neonatal outcomes: A prospective study from the IoMum Cohort

2023-10-21Journal article Open access
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dc.contributor.authorBracchi, Isabella
dc.contributor.authorGuimarães, Juliana
dc.contributor.authorRodrigues, Catarina
dc.contributor.authorAzevedo, Rui
dc.contributor.authorCoelho, Cláudia Matta
dc.contributor.authorPinheiro, Cátia
dc.contributor.authorMorais, Juliana
dc.contributor.authorBarreiros-Mota, Inês
dc.contributor.authorFernandes, Virgínia Cruz
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorPinto, Edgar
dc.contributor.authorMoreira-Rosário, André
dc.contributor.authorAzevedo, Luís Filipe Ribeiro de
dc.contributor.authorDias, Cláudia Camila
dc.contributor.authorLima, Jorge
dc.contributor.authorSapinho, Inês
dc.contributor.authorRamalho, Carla
dc.contributor.authorCalhau, Conceição
dc.contributor.authorLeite, João Costa
dc.contributor.authorAlmeida, Agostinho
dc.contributor.authorPestana, Diogo
dc.contributor.authorKeating, Elisa
dc.date.accessioned2024-04-08T14:24:23Z
dc.date.available2024-04-08T14:24:23Z
dc.date.issued2023-10-21
dc.description.abstractCobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential trace elements (ETEs) important in cellular chemical reactions and antioxidant defense. Ingestion of ETEs during pregnancy is crucial but their role in specific pregnancy outcomes is largely unknown. This study aimed to quantify urinary levels of these ETEs in pregnancy and to evaluate their role in pregnancy health. First trimester pregnant women of Porto and Lisbon regions provided a urine sample, and sociodemographic and lifestyle data. Clinical data were obtained from clinical records. Urinary ETEs were quantified by inductively coupled plasma mass spectrometry (ICP-MS). Our results show that having urinary Zn levels above the 50th percentile (P50) increases the risk of pre-eclampsia (PE). On the other hand, urinary Zn levels above the P50 decreased the risk of being born with head circumference small for gestational age but it increased the risk having length small for gestational age at birth. This study may provide valuable information for public health policies related to prenatal nutrition, while informing future efforts to de-fine urinary reference intervals for ETEs in pregnant womenpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBracchi, I., Guimarães, J., Rodrigues, C., Azevedo, R., Coelho, C. M., Pinheiro, C., Morais, J., Barreiros-Mota, I., Fernandes, V. C., Delerue-Matos, C., Pinto, E., Moreira-Rosário, A., de Azevedo, L. F. R., Dias, C. C., Lima, J., Sapinho, I., Ramalho, C., Calhau, C., Leite, J. C., … Keating, E. (2023). Essential trace elements status in portuguese pregnant women and their association with maternal and neonatal outcomes: A prospective study from the IoMum Cohort. Biology, 12(10), Artigo 10. https://doi.org/10.3390/biology12101351pt_PT
dc.identifier.doi10.3390/biology12101351pt_PT
dc.identifier.eissn2079-7737
dc.identifier.urihttp://hdl.handle.net/10400.22/25310
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThis article was supported by national funds through the FCT Foundation for Science and Technology, I.P., within the scope of the projects “RISE—LA/P/0053/2020”; CINTESIS, R&D UNIT (REFERENCE UIDB/4255/2020) and LAQV (REFERENCES: UIDB/50006/2020 and UIDP/50006/2020A). Lisbon sub-cohort set up was funded by BIAL Portela & CA, S.A. (Investigator Initiated Study, IIS). Virgínia Cruz Fernandes was funded by FCT/MCTES (Foundation for Science and Technology and Ministry of Science, Technology and Higher Education) through the projects UIDB/50006/2020, UIDP/50006/2020 and LA/P/0008/2020. Juliana Guimarães and Cátia Pinheiro were funded by FCT/MCTES (Foundation for Science and Technology and Ministry of Science, Technology and Higher Education) under CINTESIS by PhD scholarships (references UI/BD/152087/2021 and UI/BD/151504/2021, respectively).pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2079-7737/12/10/1351pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEssential trace elementspt_PT
dc.subjectPregnancypt_PT
dc.subjectPregnancy complicationspt_PT
dc.subjectPre-eclampsiapt_PT
dc.subjectNeonatal outcomespt_PT
dc.subjectNeonatal anthropometrypt_PT
dc.titleEssential trace elements status in portuguese pregnant women and their association with maternal and neonatal outcomes: A prospective study from the IoMum Cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage23pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBiologypt_PT
oaire.citation.volume12(10)pt_PT
person.familyNamePinto
person.givenNameEdgar
person.identifier.ciencia-id271F-B7DF-8FAB
person.identifier.orcid0000-0002-8021-4783
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeaf9fc86-1a1c-437f-adee-d28040aa7f2f
relation.isAuthorOfPublication.latestForDiscoveryeaf9fc86-1a1c-437f-adee-d28040aa7f2f

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