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Analytical methods for quantification of tranexamic acid in biological fluids: A review

2017Journal article Open access
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dc.contributor.authorSilva, Eduarda M.P.
dc.contributor.authorBarreiros, Luisa
dc.contributor.authorSá, Paula
dc.contributor.authorAfonso, Carlos
dc.contributor.authorKozek-Langenecker, Sibylle
dc.contributor.authorSegundo, Marcela A.
dc.date.accessioned2019-06-27T13:08:36Z
dc.date.available2020-05-02T00:30:29Z
dc.date.issued2017
dc.description.abstractTranexamic acid (TXA) is a synthetic derivative of the amino acid lysine with antifibrinolytic properties. There is still a lack of pharmacokinetic and pharmacodynamic data concerning variable age groups undergoing surgeries with high blood loss. The optimum dose and administration schedules of TXA are still subject of research, aiming at a safe inhibition of fibrinolysis in the perioperative period. Hence, effective methods for determination of TXA in biological samples are needed. The aim of this review is to discuss the required sample treatment procedures and the analytical methods applied for quantification of TXA, focusing on selected derivatisation agents and internal standards. Methods comprising a separative step (GC, LC or CZE) coupled to spectrophotometric, fluorimetric and mass spectrometry detection were considered, showing a tendency for implementation of MS/MS methods in more recent reports. Detection limits ranging from 0.01 to 0.5 μg mL− 1 in blood plasma were so far attained using LC-MS/MS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.microc.2017.06.020pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14106
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPT2020 UID/MULTI/04378/2013pt_PT
dc.relationPOCI/01/0145/FEDER/007728pt_PT
dc.relationNORTE-01-0145-FEDER-000011pt_PT
dc.relationAUTOMATION OF BIOCHEMICAL ASSAYS USING LAB-ON-VALVE AND BEAD INJECTION TECHNIQUES
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0026265X17300413pt_PT
dc.subjectAntifibrinolyticpt_PT
dc.subjectPharmacokineticpt_PT
dc.subjectDrug monitoringpt_PT
dc.subjectMass spectrometrypt_PT
dc.subjectChromatographypt_PT
dc.titleAnalytical methods for quantification of tranexamic acid in biological fluids: A reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAUTOMATION OF BIOCHEMICAL ASSAYS USING LAB-ON-VALVE AND BEAD INJECTION TECHNIQUES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FMAR%2FLA0015%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F89668%2F2012/PT
oaire.citation.endPage342pt_PT
oaire.citation.startPage333pt_PT
oaire.citation.titleMicrochemical Journalpt_PT
oaire.citation.volume134pt_PT
oaire.fundingStreamCOMPETE
person.familyNameBarreiros
person.givenNameLuisa
person.identifier.ciencia-id611F-E0C5-0230
person.identifier.orcid0000-0003-3481-5809
person.identifier.ridD-7950-2013
person.identifier.scopus-author-id6508205485
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1e66bacc-64de-4ecb-96b7-4c0e366cba57
relation.isAuthorOfPublication.latestForDiscovery1e66bacc-64de-4ecb-96b7-4c0e366cba57
relation.isProjectOfPublication3f3ecac6-bc29-4b54-a7f0-3fd636c46429
relation.isProjectOfPublicationb191ce5e-496d-4111-b415-7db84a094710
relation.isProjectOfPublication.latestForDiscovery3f3ecac6-bc29-4b54-a7f0-3fd636c46429

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