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11 - Collagen-like materials for tissue regeneration and repair

2018Book part Restricted access
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dc.contributor.authorTeixeira, Cátia
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorGomes, Paula
dc.date.accessioned2023-10-25T13:17:43Z
dc.date.available2023-10-25T13:17:43Z
dc.date.issued2018
dc.description.abstractPeptides can be designed to recreate the higher-order assembly (triple helix) and biological function of natural collagens. Collagen triple-helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are frequently proline and hydroxyproline, respectively. Glycine must be in every third position forming a hydrogen bond to an adjacent proline to stabilize collagen structure. Hydroxyproline residues are important in the thermal stability of the collagen triple-helix conformation. Although it is difficult to produce a stable triple helix, collagen-like peptides can be used to produce scaffolds that mimic natural tissue networks for biomedical engineering, without the liabilities of nonhuman natural collagens such us immunogenicity and pathogen transmission. This chapter describes the major approaches towards synthesis of collagen-like peptides, essentially aimed at production of artificial biocompatible and biofunctional frameworks for regenerative medicine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTeixeira, C., Ferraz, R., Prudêncio, C., & Gomes, P. (2018). 11—Collagen-like materials for tissue regeneration and repair. Em M. A. Barbosa & M. C. L. Martins (Eds.), Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair (pp. 283–307). Woodhead Publishing. https://doi.org/10.1016/B978-0-08-100803-4.00011-5pt_PT
dc.identifier.doi10.1016/B978-0-08-100803-4.00011-5pt_PT
dc.identifier.isbn978-0-08-100803-4
dc.identifier.urihttp://hdl.handle.net/10400.22/23774
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/B9780081008034000115?via%3Dihubpt_PT
dc.subjectCollagenpt_PT
dc.subjectChemical synthesispt_PT
dc.subjectExtracellular matrixpt_PT
dc.subjectFibrilpt_PT
dc.subjectHydroxyprolinept_PT
dc.subjectPeptidept_PT
dc.subjectProteinpt_PT
dc.subjectRegenerative medicinept_PT
dc.subjectTriple helixpt_PT
dc.title11 - Collagen-like materials for tissue regeneration and repairpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage307pt_PT
oaire.citation.startPage283pt_PT
oaire.citation.titlePeptides and Proteins as Biomaterials for Tissue Regeneration and Repairpt_PT
person.familyNameFerraz
person.familyNamePrudêncio
person.givenNameRicardo
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscovery881a8ad5-ab13-4e49-89f4-08ca61cc81e3

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