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Reading epilepsy and hyperexcitability of the visual word form area

2024-11-09Conference object Restricted access
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dc.contributor.authorBorges, Daniel Filipe
dc.contributor.authorLeal, Alberto
dc.date.accessioned2024-11-14T15:20:07Z
dc.date.available2024-11-14T15:20:07Z
dc.date.issued2024-11-09
dc.description.abstractReading epilepsy recruits critical language-related areas, with synchronization and subsequent spreading of excitation in response to the epileptogenic stimulus. The mechanism by which possible generalized discharges result in the expression of bilateral or unilateral clinical symptoms remains controversial. The cortical and subcortical areas involved may constitute part of the normal reading network, such as the visual word form area (VWFA). A right-handed, 59-year-old man was diagnosed with epilepsy at the age of 15 after tonic-clonic seizures. Later, the patient described myoclonic jerks of the masticatory and perioral muscles while reading. A multimodal approach with magnetic resonance imaging and ambulatory and video-electroencephalogram was used for seizure characterization and source analysis. A left hemisphere spontaneous occipitotemporal epileptic focus, activated by reading, was observed, spreading broadly throughout frontal and temporal language networks. There was an abnormally increased cortical response to visual word presentation in comparison to pseudowords. Spatial localization of spike sources suggested a close association between the primary epileptic focus and the VWFA. This epileptiform activity seems to be selectively triggered at an early stage of lexical processing, with a functional connection between the epileptic network and the VWFA. This multimodal and functional connectivity approach could be helpful in determining the epileptic network in reading epilepsy.
dc.description.versionN/Apt_PT
dc.identifier.citationBorges, D. F., & Leal, A. (2024, novembro). Reading epilepsy and hyperexcitability of the visual word form area. 12th Epilepsy Douro Course.
dc.identifier.urihttp://hdl.handle.net/10400.22/26402
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.subjectReading epilepsy
dc.subjectReflex epilepsy
dc.subjectVisual word form area
dc.subjectElectroencephalography
dc.subjectFunctional connectivity
dc.subjectAdaptative direct transfer function
dc.titleReading epilepsy and hyperexcitability of the visual word form areapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlace12th Epilepsy Douro Course, Portugalpt_PT
person.familyNameBorges
person.familyNameRodrigues Leal
person.givenNameDaniel Filipe
person.givenNameAlberto João
person.identifier3235598
person.identifier.ciencia-id0217-87F9-58DF
person.identifier.ciencia-id5F15-94D8-F634
person.identifier.orcid0000-0003-0189-7908
person.identifier.orcid0000-0002-3178-2530
person.identifier.ridJVO-1831-2024
person.identifier.scopus-author-id57912703700
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationf67e814a-8ad9-4440-820a-deaccea87bb8
relation.isAuthorOfPublication63fa7498-1285-4038-ac5c-9c77de39dba4
relation.isAuthorOfPublication.latestForDiscoveryf67e814a-8ad9-4440-820a-deaccea87bb8

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