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Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsies

2020Journal article Open access
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dc.contributor.authorCarvalho, Sandra
dc.contributor.authorAbreu, Catarina M.
dc.contributor.authorFerreira, Dylan
dc.contributor.authorLima, Luís
dc.contributor.authorSantos, Lúcio L.
dc.contributor.authorRibeiro, Ricardo
dc.contributor.authorGrenha, Vânia
dc.contributor.authorMartínez-Fernández, Mónica
dc.contributor.authorDuenas, Marta
dc.contributor.authorSuárez-Cabrera, Cristian
dc.contributor.authorParamio, Jesus M.
dc.contributor.authorDiéguez, Lorena
dc.contributor.authorFreitas, Paulo P.
dc.contributor.authorOliveira, Marta I.
dc.date.accessioned2020-12-03T10:23:05Z
dc.date.available2020-12-03T10:23:05Z
dc.date.issued2020
dc.description.abstractBladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrichment of urothelial exfoliated cells from fresh and frozen urine, based on deformability and size, and the cancer-associated glycan Sialyl-Tn explored as a putative bladder cancer urinary biomarker.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarvalho, S., Abreu, C. M., Ferreira, D., Lima, L., Ferreira, J. A., Santos, L. L., Ribeiro, R., Grenha, V., Martínez-Fernández, M., Duenas, M., Suárez-Cabrera, C., Paramio, J. M., Diéguez, L., Freitas, P. P., & Oliveira, M. I. (2020). Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies. Frontiers in Oncology, 10, 1774. https://doi.org/10.3389/fonc.2020.01774
dc.identifier.doi10.3389/fonc.2020.01774pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16517
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fonc.2020.01774/fullpt_PT
dc.subjectBladder cancerpt_PT
dc.subjectMicrofluidics
dc.subjectLiquid biopsy
dc.subjectUrine
dc.subjectSialyl-TnMM
dc.titlePhenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsiespt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameFerreira
person.givenNameDylan
person.identifier.ciencia-idAA12-CF31-3A82
person.identifier.orcid0000-0001-9224-0121
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication09f2b33b-0979-4d76-9495-c4fa394493a2
relation.isAuthorOfPublication.latestForDiscovery09f2b33b-0979-4d76-9495-c4fa394493a2

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