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Advisor(s)
Abstract(s)
Bladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrichment of urothelial exfoliated cells from fresh and frozen urine, based on deformability and size, and the cancer-associated glycan Sialyl-Tn explored as a putative bladder cancer urinary biomarker.
Description
Keywords
Bladder cancer Microfluidics Liquid biopsy Urine Sialyl-TnMM
Citation
Carvalho, S., Abreu, C. M., Ferreira, D., Lima, L., Ferreira, J. A., Santos, L. L., Ribeiro, R., Grenha, V., Martínez-Fernández, M., Duenas, M., Suárez-Cabrera, C., Paramio, J. M., Diéguez, L., Freitas, P. P., & Oliveira, M. I. (2020). Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies. Frontiers in Oncology, 10, 1774. https://doi.org/10.3389/fonc.2020.01774
Publisher
Frontiers Media