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Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy With Swept-Source Optical Coherence Tomography

2017Journal article Open access
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dc.contributor.authorWang, Jay C.
dc.contributor.authorLaíns, Inês
dc.contributor.authorProvidência, Joana
dc.contributor.authorArmstrong, Grayson W.
dc.contributor.authorB M Santos, Ana Rita
dc.contributor.authorGil, Pedro
dc.contributor.authorGil, João
dc.contributor.authorTalcott, Katherine E.
dc.contributor.authorMarques, João H.
dc.contributor.authorFigueira, João
dc.contributor.authorVavvas, Demetrios G.
dc.contributor.authorKim, Ivana K.
dc.contributor.authorMiller, Joan W.
dc.contributor.authorHusain, Deeba
dc.contributor.authorSilva, Rufino
dc.contributor.authorMiller, John B.
dc.date.accessioned2019-12-06T16:13:18Z
dc.date.available2019-12-06T16:13:18Z
dc.date.issued2017
dc.description.abstractPurpose To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). Design Prospective cross-sectional study. Methods Setting: Multicenter. Patient Population: Total of 143 diabetic eyes—27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 with proliferative DR (PDR)—and 64 age-matched nondiabetic control eyes. Observation Procedures: Complete ophthalmologic examination and SS-OCT imaging. En face SS-OCT images of the choroidal vasculature were binarized. Main Outcome Measures: CVD, calculated as the percent area occupied by choroidal vessels in the central macular region (6-mm-diameter circle centered on the fovea), and throughout the posterior pole (12 × 9 mm). The central macular CVV was calculated by multiplying the average CVD by macular area and choroidal thickness (obtained with SS-OCT automated software). Multilevel mixed linear models were performed for analyses. Results Compared to controls (0.31 ± 0.07), central macular CVD was significantly decreased by 9% in eyes with NPDR + DME (0.28 ± 0.06; ß = −0.03, P = .02) and by 15% in PDR (0.26 ± 0.05; ß = −0.04, P = .01). The central macular CVV was significantly decreased by 19% in eyes with PDR (0.020 ± 0.005 mm3, ß = −0.01, P = .01) compared to controls (0.025 ± 0.01 mm3). Conclusions Choroidal vascular density and volume are significantly reduced in more advanced stages of diabetic retinopathy. New imaging modalities should allow further exploration of the contributions of choroidal vessel disease to diabetic eye disease pathogenesis, prognosis, and treatment response.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ajo.2017.09.030pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/15064
dc.language.isoengpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0002939417304221?via%3Dihubpt_PT
dc.subjectChoroidpt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectDiabetic Retinopathypt_PT
dc.subjectFluorescein Angiographypt_PT
dc.subjectFundus Oculipt_PT
dc.subjectImaging, Three-Dimensionalpt_PT
dc.subjectProspective Studiespt_PT
dc.subjectRetinal Vesselspt_PT
dc.subjectTomography, Optical Coherencept_PT
dc.subjectVisual Acuitypt_PT
dc.titleDiabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy With Swept-Source Optical Coherence Tomographypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage83pt_PT
oaire.citation.startPage75pt_PT
oaire.citation.titleAmerican Journal of Ophthalmologypt_PT
oaire.citation.volume184pt_PT
person.familyNameB M Santos
person.givenNameAna Rita
person.identifier.ciencia-id291A-15C5-9C96
person.identifier.orcid0000-0003-3761-3292
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcf304315-48a2-4bae-a1d5-61a4c8e45274
relation.isAuthorOfPublication.latestForDiscoverycf304315-48a2-4bae-a1d5-61a4c8e45274

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