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Unveiling common molecular pathways linked to ILDs with progressive fibrosing phenotype: the role of MUC5B

2023-03Conference object Open access
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dc.contributor.authorSantos, Rita F.
dc.contributor.authorGonçalves, Melany
dc.contributor.authorMota, Patrícia Caetano
dc.contributor.authorCardoso, Catarina Gouveia
dc.contributor.authorCoelho, Andreia L.
dc.contributor.authorSokhatska, Oksana
dc.contributor.authorBeltrão, Marília
dc.contributor.authorGuimarães, Susana
dc.contributor.authorDelgado, Luís
dc.contributor.authorSoares, Miguel
dc.contributor.authorMorais, António
dc.contributor.authorSaraiva, Margarida
dc.contributor.authorBastos, Hélder Novais
dc.date.accessioned2024-04-19T14:17:04Z
dc.date.available2024-04-19T14:17:04Z
dc.date.issued2023-03
dc.description.abstractProgressive fibrosing ILDs (PF-ILDs) comprise a heterogeneous group of lung disorders associated with high morbidity and mortality, that exhibit a continuous worsening phenotype despite standard treatment. Among PF-ILDs are pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (HP), involving complex interactions between host genetics and different environmental triggers, shaping the immune milieu that ultimately drives the fibrotic cascade in a susceptible patient. The MUC5B promoter variant rs35705950 is the common genetic variant associated with the greatest risk of developing IPF. As IPF and fibrotic HP present phenotypic resemblances, we aim to analyze the role of rs35705950 MUC5B single nucleotide polymorphism (SNP) in common molecular pathways linked to PF-ILDs. Herein, taking advantage of our extensive ILD patients’ cohort, we found that MUC5B rs35705950 GT and TT genotypes frequency was dramatically increased in IPF and fibrotic HP compared to healthy controls.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, R. F., Gonçalves, M., Mota, P. C., Cardoso, C. G., Coelho, A. L., Sokhatska, O., Beltrão, M., Guimarães, S., Delgado, L., Soares, M., Morais, A., Saraiva, M., & Bastos, H. N. (2013). Unveiling common molecular pathways linked to ILDs with progressive fibrosing phenotype: The role of MUC5B. Trends in Biomedical Laboratory Sciences Abstract Book, 1, no1 supplement, 94.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/25379
dc.language.isoengpt_PT
dc.publisherBioMed Labpt_PT
dc.relation.publisherversionhttps://abiomedlab.org/wp-content/uploads/2023/03/I-Congresso-da-BioMedLab-Abstract-Book.pdfpt_PT
dc.subjectInterstitial lung diseasept_PT
dc.subjectHypersensitivity pneumonitispt_PT
dc.subjectMUC5Bpt_PT
dc.subjectSingle nucleotide polymorphismpt_PT
dc.subjectBronchoalveolar lavagept_PT
dc.titleUnveiling common molecular pathways linked to ILDs with progressive fibrosing phenotype: the role of MUC5Bpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPage94pt_PT
oaire.citation.titleTrends in Biomedical Laboratory Sciences Abstract Book, I Congress BioMedLabpt_PT
oaire.citation.volume1, nº1 supplementpt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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