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MicroRNA biomarkers as promising tools for early colorectal cancer screening—a comprehensive review

2023-07-03Journal article Open access
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dc.contributor.authorSantos, Daniela A. R.
dc.contributor.authorGaiteiro, Cristiana
dc.contributor.authorSantos, Marlene
dc.contributor.authorSantos, Lúcio
dc.contributor.authorDinis-Ribeiro, Mário
dc.contributor.authorLima, Luís
dc.date.accessioned2023-09-11T15:32:51Z
dc.date.available2023-09-11T15:32:51Z
dc.date.issued2023-07-03
dc.description.abstractColorectal cancer (CRC) ranks as the third most prevalent cancer worldwide. Early detection of this neoplasia has proven to improve prognosis, resulting in a 90% increase in survival. However, available CRC screening methods have limitations, requiring the development of new tools. MicroRNA biomarkers have emerged as a powerful screening tool, as they are highly expressed in CRC patients and easily detectable in several biological samples. While microRNAs are extensively studied in blood samples, recent interest has now arisen in other samples, such as stool samples, where they can be combined with existing screening methods. Among the microRNAs described in the literature, microRNA-21-5p and microRNA-92a-3p and their cluster have demonstrated high potential for early CRC screening. Furthermore, the combination of multiple microRNAs has shown improved performance in CRC detection compared to individual microRNAs. This review aims to assess the available data in the literature on microRNAs as promising biomarkers for early CRC screening, explore their advantages and disadvantages, and discuss the optimal study characteristics for analyzing these biomarkers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, D. A. R., Gaiteiro, C., Santos, M., Santos, L., Dinis-Ribeiro, M., & Lima, L. (2023). MicroRNA Biomarkers as Promising Tools for Early Colorectal Cancer Screening—A Comprehensive Review. International Journal of Molecular Sciences, 24(13), 11023. https://doi.org/10.3390/ijms241311023pt_PT
dc.identifier.doi10.3390/ijms241311023pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.22/23503
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/24/13/11023pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMicroRNApt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectBiomarkerpt_PT
dc.subjectScreeningpt_PT
dc.subjectEarly detectionpt_PT
dc.titleMicroRNA biomarkers as promising tools for early colorectal cancer screening—a comprehensive reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage23pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume24(13)pt_PT
person.familyNameSantos
person.familyNameSantos
person.givenNameDaniela A. R.
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id4617-DBEA-8AE6
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0003-1081-5142
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1f7275e9-583e-4cf2-83e1-30cde4b3b9d1
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery1f7275e9-583e-4cf2-83e1-30cde4b3b9d1

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