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Noncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in Portuguese pregnant women: results from the IoMum cohort

2022-05-30Journal article Restricted access
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dc.contributor.authorMatta Coelho, C.
dc.contributor.authorGuimarães, J.
dc.contributor.authorBracchi, I.
dc.contributor.authorXavier Moreira, N.
dc.contributor.authorPinheiro, C.
dc.contributor.authorFerreira, P.
dc.contributor.authorPestana, D.
dc.contributor.authorBarreiros Mota, I.
dc.contributor.authorCortez, A.
dc.contributor.authorPrucha, C.
dc.contributor.authorMartins, C.
dc.contributor.authorPinto, E.
dc.contributor.authorAlmeida, A.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorDias, C. C.
dc.contributor.authorMoreira-Rosário, A.
dc.contributor.authorRibeiro de Azevedo, L. F.
dc.contributor.authorFernandes, Virgínia
dc.contributor.authorRamalho, C.
dc.contributor.authorCalhau, C.
dc.contributor.authorBrantsæter, A.-L.
dc.contributor.authorCosta Leite, J.
dc.contributor.authorKeating, E.
dc.date.accessioned2023-01-27T14:47:21Z
dc.date.embargo2035
dc.date.issued2022-05-30
dc.description.abstractPurpose After a recommendation for iodine supplementation in pregnancy has been issued in 2013 in Portugal, there were no studies covering iodine status in pregnancy in the country. The aim of this study was to assess iodine status in pregnant women in Porto region and its association with iodine supplementation. Methods A cross-sectional study was conducted at Centro Hospitalar Universitário São João, Porto, from April 2018 to April 2019. Pregnant women attending the 1st trimester ultrasound scan were invited to participate. Exclusion criteria were levothyroxine use, gestational age < 10 and ≥ 14 weeks, non-evolutive pregnancy at recruitment and non-signing of informed consent. Urinary iodine concentration (UIC) was measured in random spot urine by inductively coupled plasma-mass spectrometry. Results Median UIC was 104 μg/L (IQR 62–189) in the overall population (n = 481) of which 19% had UIC < 50 µg/L. Forty three percent (n = 206) were not taking an iodine-containing supplement (ICS) and median UIC values were 146 µg/L (IQR 81–260) and 74 µg/L (IQR 42–113) in ICS users and non-users, respectively (p < 0.001). Not using an ICS was an independent risk factor for iodine insufficiency [adjusted OR (95% CI) = 6.00 (2.74, 13.16); p < 0.001]. Iodised salt use was associated with increased median iodine-to-creatinine ratio (p < 0.014). Conclusions A low compliance to iodine supplementation recommendation in pregnancy accounted for a mild-to-moderately iodine deficiency. Our results evidence the need to support iodine supplementation among pregnant women in countries with low household coverage of iodised salt.pt_PT
dc.description.sponsorshipThis article was supported by National Funds through FCT—Fundação para a Ciência e a Tecnologia,I.P., within CINTESIS, R&D Unit (reference UIDB/4255/2020); LAQV (reference UIDB/50006/2020) and through FCT postdoctoral fellowship (V.C.F., grant number SFRH/BPD/109153/2015)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s40618-022-01813-7pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21954
dc.language.isoengpt_PT
dc.publisherSpringerpt_PT
dc.relationUIDB/4255/2020pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s40618-022-01813-7pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPregnancypt_PT
dc.subjectUrinary iodinept_PT
dc.subjectIodine supplement usept_PT
dc.subjectIodine statuspt_PT
dc.subjectIodine defciencypt_PT
dc.titleNoncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in Portuguese pregnant women: results from the IoMum cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PT
oaire.citation.endPage1874pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1865pt_PT
oaire.citation.titleJournal of Endocrinological Investigationpt_PT
oaire.citation.volume45pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameDelerue-Matos
person.familyNameFernandes
person.givenNameCristina
person.givenNameVirgínia
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-id5A16-3713-E0CE
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0003-3979-7523
person.identifier.ridD-4990-2013
person.identifier.ridG-4985-2010
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id37045954500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicatione30d74c3-1a3a-4e3e-ada0-5e79362cdd6e
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519
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