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Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

2008-01-15Journal article Open access
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dc.contributor.authorVale, Nuno
dc.contributor.authorCollins, Margaret S.
dc.contributor.authorGut, Jiri
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorRosenthal, Philip J.
dc.contributor.authorCushion, Melanie T.
dc.contributor.authorMoreira, Rui
dc.contributor.authorGomes, Paula
dc.date.accessioned2022-05-09T15:29:05Z
dc.date.available2022-05-09T15:29:05Z
dc.date.issued2008-01-15
dc.description.abstractA series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 lg/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the lM range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead com pound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVale, N., Collins, M. S., Gut, J., Ferraz, R., Rosenthal, P. J., Cushion, M. T., Moreira, R., & Gomes, P. (2008). Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorganic & Medicinal Chemistry Letters, 18(2), 485-488. https://doi.org/https://doi.org/10.1016/j.bmcl.2007.11.105pt_PT
dc.identifier.doi10.1016/j.bmcl.2007.11.105pt_PT
dc.identifier.eissn1464-3405
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/10400.22/20459
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0960894X07014163?via%3Dihubpt_PT
dc.subjectAIDSpt_PT
dc.subjectAntimalarialpt_PT
dc.subjectAntiplasmodialpt_PT
dc.subjectHIVpt_PT
dc.subjectInfectionpt_PT
dc.subjectMalariapt_PT
dc.subjectPlasmodium falciparumpt_PT
dc.subjectPneumocystis cariniipt_PT
dc.subjectPrimaqpt_PT
dc.titleAnti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-onespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage488pt_PT
oaire.citation.startPage485pt_PT
oaire.citation.titleBioorganic & Medicinal Chemistry Letterspt_PT
oaire.citation.volume18pt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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