| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 124.21 KB | Adobe PDF | |||
| 1.74 KB | License |
Orientador(es)
Resumo(s)
A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 lg/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the lM range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead com pound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.
Descrição
Palavras-chave
AIDS Antimalarial Antiplasmodial HIV Infection Malaria Plasmodium falciparum Pneumocystis carinii Primaq
Contexto Educativo
Citação
Vale, N., Collins, M. S., Gut, J., Ferraz, R., Rosenthal, P. J., Cushion, M. T., Moreira, R., & Gomes, P. (2008). Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorganic & Medicinal Chemistry Letters, 18(2), 485-488. https://doi.org/https://doi.org/10.1016/j.bmcl.2007.11.105
Editora
Elsevier