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CS genetic variants affect the stability of the CS-Eculizumab Complex

2026Póster em conferência Acesso aberto
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dc.contributor.authorPeixoto, Vanda
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorVieira, Mónica
dc.contributor.authorSousa, Sérgio F.
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorAlmeida Vieira, Mónica Andreia
dc.contributor.authorPeixoto, Vanda
dc.date.accessioned2026-10-20T09:39:07Z
dc.date.available2026-10-20T09:39:07Z
dc.date.issued2026
dc.description.abstractThe monoclonal antibody eculizumab targets complement protein CS. It is a treatment for disorders involving complement system dysregulation, such as the rare disease Paroxysmal Nocturnal Hemoglobinuria (PNH). PNH is an acquired condition affecting hematopoietic stem cells, leading to abnormal red blood cell destruction, chronic hemolytic anemia, and increased risk of thrombosis 1,2. This study applies molecular dynamics simulations to explore the molecular interactions between C5 and eculizumab. It focuses on how specific single-nucleotide polymorphisms in the C5 gene -particularly the Arg88ºHis and Arg88õCys variants - may alter the protein's structure and compromise its binding with the antibody. The findings indicate that these mutations cause conformational changes at key interaction sites reducing the stability of the C5-eculizumab complex. These insights help explain reduced treatment responses in patients carrying these mutations and may support the development of improved therapeutic strategies.eng
dc.identifier.citationPeixoto, V., Prudêncio, C., Vieira, M., & Sousa, S. F. (2025). CS genetic variants affect the stability of the CS-Eculizumab Complex. Book of Abstracts of the 7th Meeting on Medicinal Biotechnology - 3rd Iberian Congress on Medicinal Biotechnology, 27.
dc.identifier.urihttp://hdl.handle.net/10400.22/32957
dc.language.isoeng
dc.peerreviewedn/a
dc.rights.uriN/A
dc.subjectComputational simulation
dc.subjectEculizumab
dc.subjectComplement C5
dc.subjectGenetic polymorphisms
dc.titleCS genetic variants affect the stability of the CS-Eculizumab Complexeng
dc.typeconference poster
dspace.entity.typePublication
oaire.citation.conferenceDate2025-05-30
oaire.citation.conferencePlacePorto
oaire.citation.startPage27
oaire.citation.titleBook of Abstracts of the 7th Meeting on Medicinal Biotechnology - 3rd Iberian Congress on Medicinal Biotechnology
oaire.versionhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43
person.familyNamePrudêncio
person.familyNameAlmeida Vieira
person.familyNamePeixoto
person.givenNameCristina
person.givenNameMónica Andreia
person.givenNameVanda
person.identifier1200571
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-idA01E-9178-9B48
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0002-8687-4811
person.identifier.orcid0000-0003-4883-3186
person.identifier.scopus-author-id6508057930
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication861e9c68-4ecc-4be1-a794-852343368e9a
relation.isAuthorOfPublicationaf5cb379-3640-49bc-9d0a-43dd212821a1
relation.isAuthorOfPublication.latestForDiscovery881a8ad5-ab13-4e49-89f4-08ca61cc81e3

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