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Within-host and synaptic transmissions: contributions to the spread of HIV infection

2016Journal article Restricted access
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dc.contributor.authorCarvalho, Ana R.M.
dc.contributor.authorPinto, Carla M.A.
dc.date.accessioned2017-01-17T11:06:59Z
dc.date.embargo2116
dc.date.issued2016
dc.description.abstractWe study the contributions of within-host (virus-to-cell) and synaptic (cell-to-cell) transmissions in a mathematical model for human immunodeficiency virus epidemics. The model also includes drug resistance. We prove the local and global stability of the disease-free equilibrium and the local stability of the endemic equilibrium. We analyse the effect of the cell-to-cell transmission rate on the value of the reproduction number, R0. Moreover, we show evidence of a qualitative change in the models’ dynamics, subjected to the value of the drug efficacy. In the end, important inferences are drawn.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/mma.4047pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/9282
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.ispartofseriesMathematical Methods in the Applied Sciences;
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/mma.4047/fullpt_PT
dc.subjectHIVpt_PT
dc.subjectSynaptic transmissionpt_PT
dc.subjectWithin-host transmissionpt_PT
dc.subjectTreatmentpt_PT
dc.subjectDrug resistancept_PT
dc.titleWithin-host and synaptic transmissions: contributions to the spread of HIV infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage34pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMathematical Methods in the Applied Sciencespt_PT
person.familyNamePinto
person.givenNameCarla
person.identifier.orcid0000-0002-0729-1133
person.identifier.ridJ-5221-2013
person.identifier.scopus-author-id14326048800
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationedfd0bf4-9f73-47ee-817a-860e3d088994
relation.isAuthorOfPublication.latestForDiscoveryedfd0bf4-9f73-47ee-817a-860e3d088994

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