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Influence of KRAS activation in the colorectal cancer immunosurveillance escape

2018-05-18Conference object Open access
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dc.contributor.authorMachado, Ana Luísa
dc.contributor.authorMendonça, S.
dc.contributor.authorCarvalho, P. Dias
dc.contributor.authorMartins, F.
dc.contributor.authorOliveira, M. J.
dc.contributor.authorVelho, S.
dc.date.accessioned2024-06-14T13:13:18Z
dc.date.available2024-06-14T13:13:18Z
dc.date.issued2018-05-18
dc.description.abstractThe immune system as a host defense system watches the cell growth and division, eliminating cells with antigens different from those present in healthy cells. However, some transformed cells have the capacity, through various mechanisms, to escape the immune system. Genomic instability and some mutations are pointed as possible mechanisms supporting the immunosurveillance escape, as is the case of KRAS mutation. This oncogenic mutation is present in about 30% of cases of colorectal cancer and confers to the tumor a greater potential for malignancy. It is known that KRAS mutant cancer cells regulate the recruitment, activation, and differentiation of immune cells, promoting tumor evolution by ensuring leakage to the immune system and increasing the proliferative potential. Few evidence highlights an association between a KRAS mutation and myeloid cells, mainly macrophages and neutrophils infiltration. However, the mechanism which determines this interaction remains unclear. Due to the growing knowledge of different immunosuppressive molecules, it became interesting to investigate if there is an alteration in these molecules related to the KRAS activation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado, A. L., Mendonça, S., Carvalho, P. D., Martins, F., Oliveira, M. J., & Velho, S. (2018). Influence of KRAS activation in the colorectal cancer immunosurveillance escape. Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnology, 19. https://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdfpt_PT
dc.identifier.isbn978-989-20-8533-3
dc.identifier.urihttp://hdl.handle.net/10400.22/25655
dc.language.isoengpt_PT
dc.publisherEscola Superior de Saúde P.Portopt_PT
dc.relation.publisherversionhttps://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdfpt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectKRAS mutationpt_PT
dc.subjectImmune surveillancept_PT
dc.subjectMacrophagespt_PT
dc.titleInfluence of KRAS activation in the colorectal cancer immunosurveillance escapept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
oaire.citation.startPage19pt_PT
oaire.citation.titleBook of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnologypt_PT
person.familyNameMarinho da Cunha Machado
person.givenNameAna Luísa
person.identifier.ciencia-idFD17-C208-D4FE
person.identifier.orcid0000-0001-6487-0679
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationd0831789-5838-47e9-a24c-53733a338419
relation.isAuthorOfPublication.latestForDiscoveryd0831789-5838-47e9-a24c-53733a338419

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