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IL6-174G > C genetic polymorphism influences antidepressant treatment outcome

2016Journal article Open access
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dc.contributor.authorCarvalho, Serafim
dc.contributor.authorSantos, Marlene
dc.contributor.authorLima, Luís
dc.contributor.authorMota-Pereira, Jorge
dc.contributor.authorPimentel, Paulo
dc.contributor.authorMaia, Dulce
dc.contributor.authorCorreia, Diana
dc.contributor.authorGomes, Sofia
dc.contributor.authorCruz, Agostinho
dc.contributor.authorMedeiros, Rui
dc.date.accessioned2017-01-20T14:29:57Z
dc.date.available2017-10-31T01:30:26Z
dc.date.issued2016
dc.description.abstractMajor depressive disorder is a condition associated with dysregulated cytokine levels; among these, IL6. Furthermore, genetic variations within cytokine genes have been proposed to predict antidepressant treatment outcome. This study aims to evaluate the role of IL6-174G > C and IL6R D358A A > C functional poly-morphisms in antidepressant treatment phenotypes, specifically remission, relapse, and treatment resistant depression (TRD). The referred polymorphisms were genotyped in 80 MDD patients followed at Hospital Magalh~aes Lemos, Portugal, within a period of 27 months. It was found that patients carrying IL6-174 GC genotype present a protection towards the development of TRD (OR ¼ 0.242; 95% CI ¼ 0.068–0.869; p ¼ .038), when compared with GG genotype. Additionally, carriers of IL6-174 CC genotype remit earlier than patients with IL6-174 GG/GC genotypes, with a median time to remission of 6 weeks for CC carriers and 15 weeks for GG or GC carriers (p ¼ .030, Log-rank test). No association was found between IL6R D358A genetic polymorphism and any of the treatment phenotypes evaluated. The IL6-174G > C polymorphism influences antidepressant treatment outcome in this sub-set of MDD patients, providing a putative mechanistic link for the dysregulated IL-6 levels described in the literature in patients with TRD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarvalho, S., Santos, M., Lima, L., Mota-Pereira, J., Pimentel, P., Maia, D., Correia, D., Gomes, S., Cruz, A., & Medeiros, R. (2017). IL6-174G > C genetic polymorphism influences antidepressant treatment outcome. Nordic Journal of Psychiatry, 71(2), 158–162. https://doi.org/10.1080/08039488.2016.1242650
dc.identifier.doi10.1080/08039488.2016.1242650pt_PT
dc.identifier.issn1502-4725
dc.identifier.urihttp://hdl.handle.net/10400.22/9333
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttp://www.tandfonline.com/doi/abs/10.1080/08039488.2016.1242650?journalCode=ipsc20pt_PT
dc.subjectIL6pt_PT
dc.subjectGenetic polymorphismspt_PT
dc.subjectAntidepressantspt_PT
dc.subjectTreatment resistant depressionpt_PT
dc.titleIL6-174G > C genetic polymorphism influences antidepressant treatment outcomept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage162pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage158pt_PT
oaire.citation.titleNordic Journal of Psychiatrypt_PT
oaire.citation.volume71pt_PT
person.familyNameSantos
person.familyNameOliveira Lima
person.familyNameCruz
person.givenNameMarlene
person.givenNameLuís Carlos
person.givenNameAgostinho
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.ciencia-id9F16-0E29-D9FC
person.identifier.orcid0000-0001-5020-5942
person.identifier.orcid0000-0001-8152-9237
person.identifier.orcid0000-0002-1157-8196
person.identifier.scopus-author-id57110502000
person.identifier.scopus-author-id23501978900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublicationc6b00c1f-f4c9-4f4f-b291-17cf30b1e1f8
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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