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In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent

2017Journal article Open access
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dc.contributor.authorLustosa, Ana
dc.contributor.authorOliveira, Antônia de Jesus
dc.contributor.authorQuelemes, Patrick
dc.contributor.authorPlácido, Alexandra
dc.contributor.authorSilva, Francilene da
dc.contributor.authorOliveira, Irisdalva
dc.contributor.authorAlmeida, Miguel de
dc.contributor.authorAmorim, Adriany
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorOliveira, Rita de
dc.contributor.authorSilva, Durcilene da
dc.contributor.authorEaton, Peter
dc.contributor.authorLeite, José de Almeida
dc.date.accessioned2019-04-12T11:28:19Z
dc.date.available2019-04-12T11:28:19Z
dc.date.issued2017
dc.description.abstractSilver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles. The nanoparticles were prepared in the hydrogel in situ, utilizing two variants of cashew gum as a capping agent, and sodium borohydride as the reducing agent. This gum is non-toxic and comes from a renewable natural source. The particles and gel were thoroughly characterized through using rheological measurements, UV-vis spectroscopy, nanoparticles tracking analysis, and transmission electron microscopy analysis (TEM). Antibacterial tests were carried out, confirming antimicrobial action of the silver nanoparticle-loaded gels. Furthermore, rat wound-healing models were used and demonstrated that the gels exhibited improved wound healing when compared to the base hydrogel as a control. Thus, these gels are proposed as excellent candidates for use as wound-healing treatments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms18112399pt_PT
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.22/13536
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/18/11/2399pt_PT
dc.subjectSilver nanoparticlespt_PT
dc.subjectHydrogelpt_PT
dc.subjectCashew gumpt_PT
dc.subjectHealingpt_PT
dc.subjectWoundspt_PT
dc.subjectAntibacterial activitypt_PT
dc.titleIn Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPage2399pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume18pt_PT
person.familyNameDelerue-Matos
person.givenNameCristina
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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