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Ionic liquids as active pharmaceutical ingredients

2011-05Journal article Open access
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dc.contributor.authorFerraz, Ricardo
dc.contributor.authorBranco, Luís C.
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorNoronha, João Paulo
dc.contributor.authorPetrovski, Željko
dc.date.accessioned2021-09-28T08:07:36Z
dc.date.available2021-09-28T08:07:36Z
dc.date.issued2011-05
dc.description.abstractIonic liquids (ILs) are ionic compounds that possess a melting temperature below 100 °C. Their physical and chemical properties are attractive for various applications. Several organic materials that are now classified as ionic liquids were described as far back as the mid-19th century. The search for new and different ILs has led to the progressive development and application of three generations of ILs: 1) The focus of the first generation was mainly on their unique intrinsic physical and chemical properties, such as density, viscosity, conductivity, solubility, and high thermal and chemical stability. 2) The second generation of ILs offered the potential to tune some of these physical and chemical properties, allowing the formation of “task-specific ionic liquids” which can have application as lubricants, energetic materials (in the case of selective separation and extraction processes), and as more environmentally friendly (greener) reaction solvents, among others. 3) The third and most recent generation of ILs involve active pharmaceutical ingredients (API), which are being used to produce ILs with biological activity. Herein we summarize recent developments in the area of third-generation ionic liquids that are being used as APIs, with a particular focus on efforts to overcome current hurdles encountered by APIs. We also offer some innovative solutions in new medical treatment and delivery options.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerraz, R., Branco, L. C., Prudêncio, C., Noronha, J. P., & Petrovski, Ž. (2011). Ionic Liquids as active pharmaceutical ingredients. ChemMedChem, 6(6), 975-985. https://doi.org/https://doi.org/10.1002/cmdc.201100082pt_PT
dc.identifier.doi10.1002/cmdc.201100082pt_PT
dc.identifier.issn1860-7187
dc.identifier.urihttp://hdl.handle.net/10400.22/18584
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWilleypt_PT
dc.relation.publisherversionhttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201100082pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDrugspt_PT
dc.subjectIonic liquidspt_PT
dc.subjectPharmaceutical activitypt_PT
dc.subjectMedicinal chemistrypt_PT
dc.titleIonic liquids as active pharmaceutical ingredientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage985pt_PT
oaire.citation.startPage975pt_PT
oaire.citation.titleChemMedChempt_PT
oaire.citation.volume6pt_PT
person.familyNameFerraz
person.familyNamePrudêncio
person.givenNameRicardo
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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