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Glioma behavior under the influence of Cinnamic Acid: a cellular approach
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Orientador(es)
Resumo(s)
Cancer is one of the biggest health problems worldwide, characterized by uncontrolled proliferation, rapid growth and the ability to invade other tissues (1). Gliomas are highly challenging tu-mours from a therapeutic perspective, so new and more effective therapeutic strategies have been in-vestigated, with particular focus on the therapeu-tic potential of plant-derived compounds, such as Cinnamic Acid (2,3). Cinnamic Acid, extracted from Cinnamomum cassia, has proved to be a promising therapeutic agent, as it exhibits antitumor properties and low cytotoxicity toward healthy cells (4–6). This phenolic compound has the ability to cross the blood-brain barrier and affect tumour cell survival by reduc-ing their proliferation rate, inducing apoptosis and inhibiting key signalling pathways involved in tumour growth (7–9). This study aims to evaluate the glioma behaviour under the influence of cinnamic acid, using a GL261 cell model. To this end, cells were cultured and treated with different concentrations of cinnamic acid (1x10-3 mol/L to 4x10-3 mol/L), followed by in vi-tro assays to assess its impact on cell viability and cell migration. The MTT assay performed on the GL261 cell line demonstrated that Cinnamic Acid is capable of reducing cell viability at all tested concentrations, with a cytotoxic effect that tends to be dose-dependent. At lower concentrations (1x10-3 mol/L and 2x10-3 mol/L), cell viability was approximately 83% (SD=13,3% and 13,9%, respectively) and the most pronounced reduc-tion in cell viability was detected at the highest tested concentration (4x10-3 mol/L), with a viability of 76% ± 13,9%, corresponding to an approximately 24% re-duction relative to the control (viability of 100%).
Descrição
Palavras-chave
Glioma Cinnamic acid Antitumoral effects Therapeutic potential Cell culture Mtt assay
Contexto Educativo
Citação
Moreira, A., Almeida, J., & Ferraz, R. (2026). Glioma behavior under the influence of Cinnamic acid: A cellular approach. Book of Abstracts of the 8th Meeting on Medicinal Biotechnology, 19. https://edicoes.ipp.pt/index.php/books/catalog/book/251
Editora
Politema