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Marine cyanobacteria compounds with anticancer properties: a review on the implication of apoptosis

2012Journal article Open access
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dc.contributor.authorCosta, Margarida
dc.contributor.authorCosta-Rodrigues, Joao
dc.contributor.authorFernandes, Maria Helena
dc.contributor.authorBarros, Piedade
dc.contributor.authorVasconcelos, Vítor
dc.contributor.authorMartins, Rosario
dc.date.accessioned2013-06-19T14:32:42Z
dc.date.available2013-06-19T14:32:42Z
dc.date.issued2012
dc.description.abstractMarine cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce cytoxicity, anti-inflammatory and antibacterial activities. The potential of marine cyanobacteria as anticancer agents has however been the most explored and, besides cytotoxicity in tumor cell lines, several compounds have emerged as templates for the development of new anticancer drugs. The mechanisms implicated in the cytotoxicity of marine cyanobacteria compounds in tumor cell lines are still largely overlooked but several studies point to an implication in apoptosis. This association has been related to several apoptotic indicators such as cell cycle arrest, mitochondrial dysfunctions and oxidative damage, alterations in caspase cascade, alterations in specific proteins levels and alterations in the membrane sodium dynamics. In the present paper a compilation of the described marine cyanobacterial compounds with potential anticancer properties is presented and a review on the implication of apoptosis as the mechanism of cell death is discussed.por
dc.description.sponsorshipPTDC/MAR/102638/2008; PTDC/MAR/099642/2008; PTDC/MAR/102258/2008;Pest-C/MAR/LA0015/2011; BTI/PTDC/MAR/102638/2008/2010-025por
dc.identifier.citationCosta, M., Costa-Rodrigues, J., Fernandes, M. H., Barros, P., Vasconcelos, V., & Martins, R. (2012). Marine Cyanobacteria Compounds with Anticancer Properties: A Review on the Implication of Apoptosis. Marine Drugs, 10(10), 2181–2207. https://doi.org/10.3390/md10102181
dc.identifier.doi10.3390/md10102181pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.22/1722
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPI
dc.subjectCancerpor
dc.subjectApoptosispor
dc.subjectMarine cyanobacteriapor
dc.subjectBioactive compoundspor
dc.titleMarine cyanobacteria compounds with anticancer properties: a review on the implication of apoptosispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2207por
oaire.citation.startPage2181por
oaire.citation.titleMarine Drugspor
oaire.citation.volumeVol. 10por
person.familyNameCosta-Rodrigues
person.familyNameGonçalves de Barros
person.familyNameMartins
person.givenNameJoao
person.givenNamePiedade Aurora
person.givenNameRosario
person.identifier.ciencia-id7412-B006-2120
person.identifier.ciencia-idD210-6003-454B
person.identifier.ciencia-idA919-DB40-EF10
person.identifier.orcid0000-0003-1375-8067
person.identifier.orcid0000-0002-2635-251X
person.identifier.orcid0000-0002-9882-4651
person.identifier.scopus-author-id8558383400
person.identifier.scopus-author-id23981959400
person.identifier.scopus-author-id21834368700
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationce85cc8f-09f3-4c26-aeaf-6128971acf68
relation.isAuthorOfPublicationa85b368a-8f13-45eb-a744-7c5810a38e2c
relation.isAuthorOfPublication82a7c349-c88e-450f-adc7-3331d69149cf
relation.isAuthorOfPublication.latestForDiscovery82a7c349-c88e-450f-adc7-3331d69149cf

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