Publication
Direct electroanalytical determination of fluvastatin in a pharmaceutical dosage form: batch and flow analysis
| dc.contributor.author | Neves, Marta M. P. S. | |
| dc.contributor.author | Nouws, Henri P. A. | |
| dc.contributor.author | Delerue-Matos, Cristina | |
| dc.date.accessioned | 2013-11-26T10:38:09Z | |
| dc.date.available | 2013-11-26T10:38:09Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | The reduction of luvastatin (FLV) at a hanging mercury-drop electrode (HMDE) was studied by square-wave adsorptive-stripping voltammetry (SWAdSV). FLV can be accumulated and reduced at the electrode, with a maximum peak current intensity at a potential of approximately 1.26V vs. AgCl=Ag, in an aqueous electrolyte solution of pH 5.25. The method shows linearity between peak current intensity and FLV concentration between 1.0 10 8 and 2.7 10 6 mol L 1. Limits of detection (LOD) and quantification (LOQ) were found to be 9.9 10 9 mol L 1 and 3.3 10 8 mol L 1, respectively. Furthermore, FLV oxidation at a glassy carbon electrode surface was used for its hydrodynamic monitoring by amperometric detection in a flow-injection system. The amperometric signal was linear with FLV concentration over the range 1.0 10 6 to 1.0 10 5 mol L 1, with an LOD of 2.4 10 7 mol L 1 and an LOQ of 8.0 10 7 mol L 1. A sample rate of 50 injections per hour was achieved. Both methods were validated and showed to be precise and accurate, being satisfactorily applied to the determination of FLV in a commercial pharmaceutical. | por |
| dc.identifier.doi | 10.1080/00032710802421889 | pt_PT |
| dc.identifier.issn | 0003-2719 | |
| dc.identifier.issn | 1532-236X | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/2951 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Taylor & Francis | por |
| dc.relation.ispartofseries | Analytical Letters; Vol. 41, Issue 15 | |
| dc.relation.publisherversion | http://www.tandfonline.com/doi/abs/10.1080/00032710802421889#.UooaQH9qyZQ | por |
| dc.subject | Adsorptive-stripping voltammetry | por |
| dc.subject | Amperometric detection | por |
| dc.subject | Flow injection analysis | por |
| dc.subject | Fluvastatin | por |
| dc.subject | Hanging mercury drop electrode | por |
| dc.subject | Pharmaceutical analysis | por |
| dc.title | Direct electroanalytical determination of fluvastatin in a pharmaceutical dosage form: batch and flow analysis | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 2804 | por |
| oaire.citation.startPage | 2794 | por |
| oaire.citation.title | Analytical Letters | por |
| person.familyName | Delerue-Matos | |
| person.givenName | Cristina | |
| person.identifier.ciencia-id | 9A1A-43FB-5C27 | |
| person.identifier.orcid | 0000-0002-3924-776X | |
| person.identifier.rid | D-4990-2013 | |
| person.identifier.scopus-author-id | 6603741848 | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | 09f6a7bd-2f15-42b0-adc5-04bd22210519 | |
| relation.isAuthorOfPublication.latestForDiscovery | 09f6a7bd-2f15-42b0-adc5-04bd22210519 |