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Direct electroanalytical determination of fluvastatin in a pharmaceutical dosage form: batch and flow analysis
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Orientador(es)
Resumo(s)
The reduction of luvastatin (FLV) at a hanging mercury-drop electrode
(HMDE) was studied by square-wave adsorptive-stripping voltammetry
(SWAdSV). FLV can be accumulated and reduced at the electrode, with a
maximum peak current intensity at a potential of approximately 1.26V vs.
AgCl=Ag, in an aqueous electrolyte solution of pH 5.25. The method shows linearity
between peak current intensity and FLV concentration between 1.0 10 8
and 2.7 10 6 mol L 1. Limits of detection (LOD) and quantification (LOQ)
were found to be 9.9 10 9 mol L 1 and 3.3 10 8 mol L 1, respectively.
Furthermore, FLV oxidation at a glassy carbon electrode surface was used
for its hydrodynamic monitoring by amperometric detection in a flow-injection
system. The amperometric signal was linear with FLV concentration over the
range 1.0 10 6 to 1.0 10 5 mol L 1, with an LOD of 2.4 10 7 mol L 1
and an LOQ of 8.0 10 7 mol L 1. A sample rate of 50 injections per hour
was achieved.
Both methods were validated and showed to be precise and accurate, being
satisfactorily applied to the determination of FLV in a commercial pharmaceutical.
Descrição
Palavras-chave
Adsorptive-stripping voltammetry Amperometric detection Flow injection analysis Fluvastatin Hanging mercury drop electrode Pharmaceutical analysis
Contexto Educativo
Citação
Editora
Taylor & Francis