Repository logo
 
Publication

Bioactive peptides from milk proteins with antioxidant, anti-inflammatory, and antihypertensive activities

2025-02-06Research article Open access
Simple item page
dc.contributor.authorBorges, Thaís
dc.contributor.authorCoelho, Pedro
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorGomes, Ana
dc.contributor.authorGomes, Paula
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorCoelho, Pedro
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorFerraz, Ricardo
dc.date.accessioned2025-04-08T10:24:27Z
dc.date.available2025-04-08T10:24:27Z
dc.date.issued2025-02-06
dc.description.abstractPeptides from protein ingredients exhibit key biological activities, including antimicrobial, antihypertensive, antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Aligning with the One Health approach, there is growing investment in promoting pet health and well-being. As a result, sustainable functional ingredients are increasingly essential for pet food development. In this work, peptides derived from lactoferrins of different mammalian species were synthesized and their antioxidant, anti-inflammatory, and antihypertensive activities were investigated. This study examined the antioxidant, anti-inflammatory, antihypertensive activities, and cytotoxicity of bioactive peptides derived from lactoferrins of various mammalian species through spectroscopical methods. The peptides were produced via chemical synthesis (bottom-up approach). Peptides derived from bovine lactoferrin showed the most promising antioxidant and anti-inflammatory activities, whereas those derived from human lactoferrin showed the highest antihypertensive effects and the lowest cytotoxicity. In short, milk-derived peptides with antioxidant, anti-inflammatory, and antihypertensive activity were identified. This motivates further studies to better characterize these peptides, including their properties and pharmacokinetics in vivo, to assess their true potential as nutraceutical agents.por
dc.description.sponsorship2022.08044.CEECIND/CP1724/CT0004
dc.identifier.citationBorges, T., Coelho, P., Prudêncio, C., Gomes, A., Gomes, P., & Ferraz, R. (2025). Bioactive peptides from milk proteins with antioxidant, anti-inflammatory, and antihypertensive activities. Foods, 14(3), Artigo 3. https://doi.org/10.3390/foods14030535
dc.identifier.doi10.3390/foods14030535
dc.identifier.eissn2304-8158
dc.identifier.urihttp://hdl.handle.net/10400.22/29936
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationLA/P/0008/2020; UIDB/50006/2020 ; PTDC/BAA-AGR/4923/2021
dc.relation.hasversionhttps://www.mdpi.com/2304-8158/14/3/535#
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBioactive peptides
dc.subjectMilk proteins
dc.subjectAntioxidant
dc.subjectAnti-inflammatory
dc.subjectAntihypertensive
dc.titleBioactive peptides from milk proteins with antioxidant, anti-inflammatory, and antihypertensive activitiespor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.titleFoods
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCoelho
person.familyNamePrudêncio
person.familyNameFerraz
person.givenNamePedro
person.givenNameCristina
person.givenNameRicardo
person.identifier1200571
person.identifier.ciencia-idBE18-3DB2-8D79
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-2343-1108
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridAAZ-9239-2020
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id57214054449
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id24464208500
relation.isAuthorOfPublicationeb030614-4140-437b-8ac3-f59c52566ecf
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoveryeb030614-4140-437b-8ac3-f59c52566ecf

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ART_Ricardo Ferraz.pdf
Size:
465.45 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESS - TBIO - Artigos
ESS - CQB - Artigos