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- Bioactive peptides from milk proteins with antioxidant, anti-inflammatory, and antihypertensive activitiesPublication . Borges, Thaís; Coelho, Pedro; Prudêncio, Cristina; Gomes, Ana; Gomes, Paula; Ferraz, Ricardo; Coelho, Pedro; Prudêncio, Cristina; Ferraz, RicardoPeptides from protein ingredients exhibit key biological activities, including antimicrobial, antihypertensive, antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Aligning with the One Health approach, there is growing investment in promoting pet health and well-being. As a result, sustainable functional ingredients are increasingly essential for pet food development. In this work, peptides derived from lactoferrins of different mammalian species were synthesized and their antioxidant, anti-inflammatory, and antihypertensive activities were investigated. This study examined the antioxidant, anti-inflammatory, antihypertensive activities, and cytotoxicity of bioactive peptides derived from lactoferrins of various mammalian species through spectroscopical methods. The peptides were produced via chemical synthesis (bottom-up approach). Peptides derived from bovine lactoferrin showed the most promising antioxidant and anti-inflammatory activities, whereas those derived from human lactoferrin showed the highest antihypertensive effects and the lowest cytotoxicity. In short, milk-derived peptides with antioxidant, anti-inflammatory, and antihypertensive activity were identified. This motivates further studies to better characterize these peptides, including their properties and pharmacokinetics in vivo, to assess their true potential as nutraceutical agents.
- Influence of history of bronchiolitis on health-related physical fitness (muscle strength and cardiorespiratory fitness) in children and adolescents: a cross-sectional studyPublication . Carvalho, Inês Silva de; Vilarinho, Rui; Amaral, Luísa; Vilarinho, RuiA history of bronchiolitis may lead to changes in health-related physical fitness in children and adolescents. The aim of this study was to analyze the influence of history of bronchiolitis on health-related physical fitness components (muscle strength and cardiorespiratory fitness) in children and adolescents. A cross-sectional study was conducted, and 86 participants (aged 7–14 years; all males) were divided into two groups: a group with (n = 40) and without (n = 46) history of bronchiolitis. Muscle strength was assessed with handgrip and isometric quadriceps strength tests with handheld dynamometers and the five-times sit-to-stand test. Cardiorespiratory fitness was assessed with the six-minute walk test (6MWT). The Mann–Whitney test was used to compare the health-related physical fitness tests between groups and the binary logistic regression model was used to estimate the potential risk or protective factors in participants. No significant differences were observed between the groups in muscle strength tests. Participants without bronchiolitis walked a greater distance in the 6MWT than those with bronchiolitis (p = 0.002), and this appears to reproduce a protective factor in the group without bronchiolitis with an odds ratio of 0.99 [95% confidence interval: 0.98–0.99]. In this study, a history of bronchiolitis appears to influence cardiorespiratory fitness, but not muscle strength, in children and adolescents.