Repository logo
 
Publication

“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability

2020Journal article Open access
Simple item page
dc.contributor.authorGomes, Ana
dc.contributor.authorBessa, Lucinda J.
dc.contributor.authorCorreia, Patrícia
dc.contributor.authorFernandes, Iva
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorGameiro, Paula
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Paula
dc.date.accessioned2020-12-04T12:22:02Z
dc.date.available2020-12-04T12:22:02Z
dc.date.issued2020
dc.description.abstractA covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, A., Bessa, L. J., Correia, P., Fernandes, I., Ferraz, R., Gameiro, P., Teixeira, C., & Gomes, P. (2020). “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences, 21(17), 6174. https://www.mdpi.com/1422-0067/21/17/6174pt_PT
dc.identifier.doi10.3390/ijms21176174pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16530
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/21/17/6174pt_PT
dc.subjectAntibacterialpt_PT
dc.subjectAntibiofilmpt_PT
dc.subjectIonic liquidpt_PT
dc.subjectMultidrug resistancept_PT
dc.subjectPeptidept_PT
dc.subjectSkin infectionspt_PT
dc.subjectTyrosinasept_PT
dc.subjectWound healingpt_PT
dc.title“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stabilitypt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ART_Ricardo_Ferraz_II.pdf
Size:
930.05 KB
Format:
Adobe Portable Document Format
Download

Collections

ESS - CQB - Artigos