Advisor(s)
Abstract(s)
A covalent conjugate between an antibacterial ionic liquid and an antimicrobial
peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity
against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.
Description
Keywords
Antibacterial Antibiofilm Ionic liquid Multidrug resistance Peptide Skin infections Tyrosinase Wound healing
Pedagogical Context
Citation
Gomes, A., Bessa, L. J., Correia, P., Fernandes, I., Ferraz, R., Gameiro, P., Teixeira, C., & Gomes, P. (2020). “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences, 21(17), 6174. https://www.mdpi.com/1422-0067/21/17/6174