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Advisor(s)
Abstract(s)
The oxidation of codeine on glassy carbon electrodes has been studied in detail using differential pulse voltammetry.
The results obtained using a glassy carbon electrode clearly show a much more complex oxidation mechanism than
that previously reported when platinum and gold electrodes were used. To clarify the codeine oxidative profile,
several metabolites and analogues of this alkaloid, codeine N-oxide, norcodeine, dihydrocodeine, acetylcodeine and 6-
chlorodesoxycodeine, were synthesized and studied. It was deduced that the anodic waves observed in codeine
oxidation are related to the presence of methoxy, hydroxy and tertiary amine groups. Due to the similarity of
potentials at which these oxidative processes take place, at some pHs an overlap of peaks occurs and only one anodic
wave is observed.
Description
Keywords
Codeine Dihydrocodeine Codeine-N-oxide Norcodeine Acetylcodeine 6-Chlorodesoxycodeine Oxidation Voltammetry Drugs of abuse
Citation
Publisher
WILEY-VCH Verlag