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Preclinical Imaging: an Essential Ally in Modern Biosciences

2014Journal article Open access
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dc.contributor.authorCunha, Lídia
dc.contributor.authorHorvath, Ildiko
dc.contributor.authorFerreira, Sara
dc.contributor.authorLemos, Joana
dc.contributor.authorCosta, Pedro
dc.contributor.authorVieira, Domingos
dc.contributor.authorVeres, Dániel S.
dc.contributor.authorSzigeti, Krisztián
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorMáthé, Domokos
dc.contributor.authorMetello, Luís F.
dc.date.accessioned2019-12-06T12:57:51Z
dc.date.available2019-12-06T12:57:51Z
dc.date.issued2014
dc.description.abstractTranslational research is changing the practice of modern medicine and the way in which health problems are approached and solved. The use of small-animal models in basic and preclinical sciences is a major keystone for these kinds of research and development strategies, representing a bridge between discoveries at the molecular level and clinical implementation in diagnostics and/or therapeutics. The development of high-resolution in vivo imaging technologies provides a unique opportunity for studying disease in real time, in a quantitative way, at the molecular level, along with the ability to repeatedly and non-invasively monitor disease progression or response to treatment. The greatest advantages of preclinical imaging techniques include the reduction of biological variability and the opportunity to acquire, in continuity, an impressive amount of unique information (without interfering with the biological process under study) in distinct forms, repeated or modulated as needed, along with the substantial reduction in the number of animals required for a particular study, fully complying with 3R (Replacement, Reduction and Refinement) policies. The most suitable modalities for small-animal in vivo imaging applications are based on nuclear medicine techniques (essentially, positron emission tomography [PET] and single photon emission computed tomography [SPECT]), optical imaging (OI), computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance spectroscopy imaging (MRSI), and ultrasound. Each modality has intrinsic advantages and limitations. More recently, aiming to overcome the inherent limitations of each imaging modality, multimodality devices designed to provide complementary information upon the pathophysiological process under study have gained popularity. The combination of high-resolution modalities, like micro-CT or micro-MRI, with highly sensitive techniques providing functional information, such as micro-PET or micro-SPECT, will continue to broaden the horizons of research in such key areas as infection, oncology, cardiology, and neurology, contributing not only to the understanding of the underlying mechanisms of disease, but also providing efficient and unique tools for evaluating new chemical entities and candidate drugs. The added value of small-animal imaging techniques has driven their increasing use by pharmaceutical companies, contract research organizations, and research institutions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s40291-013-0062-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/15057
dc.language.isoengpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s40291-013-0062-3pt_PT
dc.subjectDiagnostic Imagingpt_PT
dc.subjectImage Interpretation, Computer-Assistedpt_PT
dc.subjectMagnetic Resonance Imagingpt_PT
dc.subjectModels, Animalpt_PT
dc.subjectPositron-Emission Tomographypt_PT
dc.subjectTomography, Emission-Computed, Single-Photonpt_PT
dc.subjectTranslational Medical Researchpt_PT
dc.titlePreclinical Imaging: an Essential Ally in Modern Biosciencespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage173pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage153pt_PT
oaire.citation.titleMolecular Diagnosis and Therapypt_PT
oaire.citation.volume18pt_PT
person.familyNameCunha
person.familyNameLemos
person.familyNameCosta
person.familyNameSummavielle
person.givenNameLídia
person.givenNameJoana
person.givenNamePedro
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-id3F11-3268-F06A
person.identifier.ciencia-idDA11-C4E7-D9D1
person.identifier.ciencia-id991E-B484-9248
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0002-9260-8093
person.identifier.orcid0000-0002-5734-7166
person.identifier.orcid0000-0002-9280-2750
person.identifier.orcid0000-0002-4094-700X
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationed51e8c5-a1c2-40e6-b976-57af77446e1b
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relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery04aa6dfe-65b2-4606-877b-3ebd15e78111

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