A carregar...
Publicação
Adaptação de ferramenta certificada para avaliação da manipulação segura de medicamentos citotóxicos
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 11.64 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
A manipulação de fármacos citotóxicos representa riscos ocupacionais significativos, exigindo ferramentas validadas para avaliar práticas de segurança baseadas em normas internacionais, necessidade evidente nos países africanos de língua oficial portuguesa (PALOP), onde os recursos são limitados. Este estudo teve como objetivo identificar e adaptar ferramentas de avaliação das práticas de manipulação de citotóxicos, nos PALOP. Foi realizada uma revisão scoping na PubMed para identificar ferramentas destinadas à avaliação de práticas de manipulação de citotóxicos. O processo de tradução para português incluiu tradução profissional e independente, retrotradução e validação linguística e cultural através da metodologia Delphi, com peritos em farmácia hospitalar e oncologia. Avaliaram-se dimensões de clareza, equivalência semântica e adequação linguística. Através do coeficiente de correlação intraclasse (ICC) e do alfa de Cronbach, analisou-se a fiabilidade estatística. Dos nove estudos identificados, destacou-se o Cyto-SAT® pela sua abrangência e adequação aos critérios definidos. A versão em português apresentou médias, medianas e modas elevadas. O ICC indicou boa a excelente consistência interna e fiabilidade interavaliadores. O Cyto-SAT® em português constitui uma ferramenta fiável e pertinente para aplicação futura nos PALOP, com potencial para reforçar a segurança ocupacional e promover práticas seguras na manipulação de citotóxicos nestes contextos.
The handling of cytotoxic drugs poses significant occupational risks, requiring validated tools to assess safety practices based on international standards - a need that is evident in Portuguese-speaking African countries (PALOP), where resources are limited. This study aimed to identify and adapt assessment tools for evaluating cytotoxic drug handling practices in the PALOP. A scoping review was conducted in PubMed to identify tools designed for this purpose. The translation process into Portuguese included a professional and an independent translation, back-translation, and linguistic and cultural validation using the Delphi methodology, involving experts in hospital pharmacy and oncology. The dimensions of clarity, semantic equivalence and linguistic adequacy were assessed. The reliability of the instrument was analyzed through the intraclass correlation coefficient (ICC) and Cronbach’s alpha. Among the nine studies identified, the Cyto-SAT® emerged as the most comprehensive and best aligned with the defined criteria. The Portuguese version demonstrated consistently high means, medians and modes. ICC values indicated good to excellent internal consistency and inter-rater reliability. The Portuguese version of the Cyto-SAT® is a reliable and relevant tool for future application in the PALOP, with the potential to strengthen occupational safety and promote safe practices in the handling of cytotoxic drugs
The handling of cytotoxic drugs poses significant occupational risks, requiring validated tools to assess safety practices based on international standards - a need that is evident in Portuguese-speaking African countries (PALOP), where resources are limited. This study aimed to identify and adapt assessment tools for evaluating cytotoxic drug handling practices in the PALOP. A scoping review was conducted in PubMed to identify tools designed for this purpose. The translation process into Portuguese included a professional and an independent translation, back-translation, and linguistic and cultural validation using the Delphi methodology, involving experts in hospital pharmacy and oncology. The dimensions of clarity, semantic equivalence and linguistic adequacy were assessed. The reliability of the instrument was analyzed through the intraclass correlation coefficient (ICC) and Cronbach’s alpha. Among the nine studies identified, the Cyto-SAT® emerged as the most comprehensive and best aligned with the defined criteria. The Portuguese version demonstrated consistently high means, medians and modes. ICC values indicated good to excellent internal consistency and inter-rater reliability. The Portuguese version of the Cyto-SAT® is a reliable and relevant tool for future application in the PALOP, with the potential to strengthen occupational safety and promote safe practices in the handling of cytotoxic drugs
Descrição
Palavras-chave
Quimioterapia Manipulação PALOP Profissionais de farmácia Cyto-SAT®