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Role of genetic polymorphisms on neuroplasticity pathways in a cohort of Portuguese patients with Major Depressive Disorder

2022Journal article Open access
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dc.contributor.authorSantos, M.
dc.contributor.authorCarvalho, S.
dc.contributor.authorLima, L.
dc.contributor.authorMota-Pereira, J.
dc.contributor.authorPimentel, P.
dc.contributor.authorCorreia, D.
dc.contributor.authorMaia, D.
dc.contributor.authorGomes, S.
dc.contributor.authorCruz, A.
dc.contributor.authorMedeiros, R.
dc.date.accessioned2023-01-19T15:20:43Z
dc.date.available2023-01-19T15:20:43Z
dc.date.issued2022
dc.description.abstractGrowing evidence suggests the implication of brain plasticity in antidepressant drug (AD) efficacy. Several authors have been pointing out the role of the BDNF-TrkB signaling pathway, including the downstream kinases Akt and ERK, and the mTOR pathway in neuroplasticity [1-3]. Furthermore, the prediction of AD response phenotypes of depressed patients treated with AD drugs remains a challenge for clinicians. Although previous studies have suggested that genetic variants may play a key role in the mechanism of Treatment Resistance Depression and Relapse, attempts to identify risk polymorphisms within genes with putative interest in AD response, had a limited success.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, M., Carvalho, S., Lima, L., Mota-Pereira, J., Pimentel, P., Correia, D., Maia, D., Gomes, S., Cruz, A., & Medeiros, R. (2022). Role of genetic polymorphisms on neuroplasticity pathways in a cohort of Portuguese patients with Major Depressive Disorder. Abstracts of the 35th ECNP Congress 2022, 1, 100975. https://doi.org/10.1016/j.nsa.2022.100975pt_PT
dc.identifier.doi10.1016/j.nsa.2022.100975pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21698
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherECNPpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2772408522009760pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleRole of genetic polymorphisms on neuroplasticity pathways in a cohort of Portuguese patients with Major Depressive Disorderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage435pt_PT
oaire.citation.titleNeuroscience Appliedpt_PT
oaire.citation.volumeVolume 1, Supplement 2pt_PT
person.familyNameSantos
person.familyNameCruz
person.givenNameMarlene
person.givenNameAgostinho
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0001-5020-5942
person.identifier.orcid0000-0002-1157-8196
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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