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Which role plays 2-Hydroxybutyric acid on Insulin resistance?

2021-12-03Journal article Open access
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dc.contributor.authorSousa, André P.
dc.contributor.authorCunha, Diogo M.
dc.contributor.authorFranco, Carolina
dc.contributor.authorTeixeira, Catarina
dc.contributor.authorGojon, Frantz
dc.contributor.authorBaylina, Pilar
dc.contributor.authorFernandes, Rúben
dc.date.accessioned2024-11-25T11:06:37Z
dc.date.available2024-11-25T11:06:37Z
dc.date.issued2021-12-03
dc.description.abstractType 2 Diabetes Mellitus (T2D) is defined as a chronic condition caused by beta cell loss and/or dysfunction and insulin resistance (IR). The discovering of novel biomarkers capable of identifying T2D and other metabolic disorders associated with IR in a timely and accurate way is critical. In this review, 2-hydroxybutyric acid (2HB) is presented as that upheaval biomarker with an unexplored potential ahead. Due to the activation of other metabolic pathways during IR, 2HB is synthesized as a coproduct of protein metabolism, being the progression of IR intrinsically related to the increasing of 2HB levels. Hence, the focus of this review will be on the 2HB metabolite and its involvement in glucose homeostasis. A literature review was conducted, which comprised an examination of publications from different databases that had been published over the previous ten years. A total of 19 articles fulfilled the intended set of criteria. The use of 2HB as an early indicator of IR was separated into subjects based on the number of analytes examined simultaneously. In terms of the association between 2HB and IR, it has been established that increasing 2HB levels can predict the development of IR. Thus, 2HB has demonstrated considerable promise as a clinical monitoring molecule, not only as an IR biomarker, but also for disease follow-up throughout IR treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSousa, A. P., Cunha, D. M., Franco, C., Teixeira, C., Gojon, F., Baylina, P., & Fernandes, R. (2021). Which role plays 2-Hydroxybutyric acid on Insulin resistance? Metabolites, 11(12), Artigo 12. https://doi.org/10.3390/metabo11120835pt_PT
dc.identifier.doi10.3390/metabo11120835pt_PT
dc.identifier.eissn2218-1989
dc.identifier.urihttp://hdl.handle.net/10400.22/26454
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2218-1989/11/12/835pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subject2-hydroxybutyric acidpt_PT
dc.subjectImpaired glucose tolerancept_PT
dc.subjectInsulin resistancept_PT
dc.subjectType 2 diabetes mellituspt_PT
dc.titleWhich role plays 2-Hydroxybutyric acid on Insulin resistance?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMetabolitespt_PT
oaire.citation.volume11(12)pt_PT
person.familyNameSousa
person.familyNameTeixeira
person.familyNameBAYLINA MACHADO
person.familyNameFernandes
person.givenNameAndré P.
person.givenNameCatarina
person.givenNamePILAR
person.givenNameRúben
person.identifier1609329
person.identifier635792
person.identifier.ciencia-id471F-9426-6FFD
person.identifier.ciencia-id1419-F23D-4920
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.orcid0000-0003-1460-5361
person.identifier.orcid0000-0001-6934-7641
person.identifier.orcid0000-0002-3740-862X
person.identifier.orcid0000-0001-8933-3984
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id56534079700
person.identifier.scopus-author-id57640135700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4f95e9e8-ed83-4437-9236-d742df2d0255
relation.isAuthorOfPublicatione7f1c558-0259-4c06-a344-21d74c197d47
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4

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