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Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: associated factors

2024Journal article Restricted access
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dc.contributor.authorFerraz Oliveira, Rita
dc.contributor.authorOliveira, Ana Isabel
dc.contributor.authorCruz, Agostinho
dc.contributor.authorRibeiro, Oscar
dc.contributor.authorAfreixo, Vera
dc.contributor.authorPimentel, Francisco
dc.date.accessioned2024-10-03T11:47:32Z
dc.date.available2024-10-03T11:47:32Z
dc.date.issued2024
dc.description.abstractPolypharmacy in older adults with cancer receiving chemotherapy leads to increased risks of drug interactions, translating in potential hazardous health outcomes. This study aims to assess the prevalence of polypharmacy, drug–drug interactions (DDIs), and severe-drug interactions (SDIs) in older patients with cancer. Antineoplastic agents (ANAs) involvement and possible risk contexts (comorbidities with cardiac risk, and high-risk medications) were also analysed. ents (ANAs); it was conducted in three hospitals from the north of Portugal. Data collection was obtained using self-reports and medical records. DDIs were identifed and classifed using Micromedex® software. Descriptive and association analyze statistics were performed. Statistical hypothesis tests with p value less than 0.05 were considered signifcant. All statistical procedures and analysis were performed with R version 4.1.3. We enrolled 552 patients. Polypharmacy prevalence was 88.40%; 76.45% and 56.16% of the patients presented with DDIs and SDIs, respectively. SDIs with ANAs were found in 21.20% of the patients. High-risk medications were associated with a higher risk of polypharmacy, DDIs, and SDIs. Polypharmacy and DDIs were higher in patients with hypertension or diabetes. SDIs were higher in patients with diabetes. Polypharmacy, potential DDIs and SDIs were highly prevalent in older adults with cancer. A careful review of the medication administered is necessary to decrease it. These fndings warrant further research to optimize medication in this population and decrease problems related to medication, which may lead to emergency room visits and hospitalisations, compromising patient safety and/or ongoing treatments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, R. F., Oliveira, A. I., Cruz, A. S., Ribeiro, O., Afreixo, V., & Pimentel, F. (2024). Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: Associated factors. BMC Geriatrics, 24(1), 557. https://doi.org/10.1186/s12877-024-05135-6pt_PT
dc.identifier.doi10.1186/s12877-024-05135-6pt_PT
dc.identifier.eissn1471-2318
dc.identifier.urihttp://hdl.handle.net/10400.22/26183
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturespt_PT
dc.relationThis study was partially supported (English editing) by national funds through FCT—Fundação para a Ciência e a Tecnologia, I.P., within CINTESIS R&D Unit (UIDB/4255/2020 and UIDP/4255/2020) and within the scope of the project RISE (LA/P/0053/2020).pt_PT
dc.relation.publisherversionhttps://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-024-05135-6pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolypharmacypt_PT
dc.subjectDrug interactionspt_PT
dc.subjectSevere drug interactionspt_PT
dc.subjectAntineoplastic agentspt_PT
dc.subjectElderly cancer patientspt_PT
dc.titlePolypharmacy and drug interactions in older patients with cancer receiving chemotherapy: associated factorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBMC Geriatricspt_PT
oaire.citation.volume24pt_PT
person.familyNameFerraz Oliveira
person.familyNameOliveira
person.familyNameCruz
person.givenNameRita
person.givenNameAna Isabel
person.givenNameAgostinho
person.identifier.ciencia-idFD1F-2E0C-1254
person.identifier.ciencia-id9212-F501-E9EF
person.identifier.orcid0000-0003-3933-5740
person.identifier.orcid0000-0003-4420-6476
person.identifier.orcid0000-0002-1157-8196
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6c1b7213-1303-47eb-bfa7-ecbef6a9b8d9
relation.isAuthorOfPublication4b3fe293-2740-469f-97d3-99d0b107b5e0
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication.latestForDiscovery6c1b7213-1303-47eb-bfa7-ecbef6a9b8d9

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