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The impact of a rectal spacer in VMAT Dosimetry in the treatment of Prostate Cancer

2025-08-27Artigo de investigação Acesso aberto
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dc.contributor.authorOliveira, Susana
dc.contributor.authorFernandes, Ruben
dc.contributor.authorBaylina, Pilar
dc.contributor.authorSantos, João
dc.contributor.authorVieira, Guy
dc.contributor.authorFaria, Isabel
dc.contributor.authorPereira, Norberto
dc.contributor.authorFernandes, Rúben
dc.contributor.authorBAYLINA MACHADO, PILAR
dc.contributor.authorSousa Pinho Faria, Isabel Maria
dc.date.accessioned2026-04-07T15:26:50Z
dc.date.available2026-04-07T15:26:50Z
dc.date.issued2025-08-27
dc.description.abstractAlthough the dosimetric advantages of rectal spacers in prostate cancer radiotherapy have been demonstrated in selected clinical trials, real-world data from routine clinical practice remain limited—particularly within the Portuguese healthcare system. This study offers a detailed dosimetric comparison of Volumetric Modulated Arc Therapy (VMAT), with and without rectal spacer use, in a real-world patient cohort, aiming to assess the clinical relevance of spacer insertion under standard treatment protocols. A retrospective dosimetric evaluation was performed on 80 prostate cancer patients treated at a radiotherapy centre in southern Portugal. Patients were equally divided into two matched groups (n = 40): one receiving VMAT alone, the other receiving VMAT with hydrogel rectal spacer placement. Dose-volume histograms (DVHs) were analysed for the planning target volume (PTV) and key organs at risk (OARs). Standard dosimetric metrics, such as V50–V75 for the rectum and bladder, V50 for femoral heads, and mean dose for the penile bulb, were assessed. PTV coverage was evaluated using conformity and homogeneity indices. Spacer use significantly decreased rectal dose exposure across all evaluated parameters without compromising PTV coverage or increasing dose to other OARs. These findings support routine rectal spacer applications to enhance treatment safety and patient outcomes.eng
dc.identifier.citationOliveira, S., Fernandes, R., Baylina, P., Santos, J., Vieira, G., Faria, I., & Pereira, N. (2025). The Impact of a Rectal Spacer in VMAT Dosimetry in the Treatment of Prostate Cancer. Applied Sciences, 15(17), 9414. https://doi.org/10.3390/app15179414
dc.identifier.doi10.3390/app15179414
dc.identifier.eissn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.22/32189
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://www.mdpi.com/2076-3417/15/17/9414
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectOrgans at risk
dc.subjectProstate cancer
dc.subjectRectal spacer
dc.subjectVMAT
dc.subjectClinical dosimetry
dc.subjectRadiotherapy
dc.titleThe impact of a rectal spacer in VMAT Dosimetry in the treatment of Prostate Cancereng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue17
oaire.citation.titleApplied Sciences
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFernandes
person.familyNameBAYLINA MACHADO
person.familyNameSousa Pinho Faria
person.givenNameRúben
person.givenNamePILAR
person.givenNameIsabel Maria
person.identifier635792
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.ciencia-id1419-F23D-4920
person.identifier.orcid0000-0001-8933-3984
person.identifier.orcid0000-0002-3740-862X
person.identifier.orcid0000-0002-1467-7800
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id57640135700
person.identifier.scopus-author-id56534079700
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublicationb74bdeca-0113-40a8-ba5a-8fe2d558fe0e
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4

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