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Bone injury and repair trigger central and peripheral NPY Neuronal Pathways

2016Journal article Open access
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dc.contributor.authorAlves, Cecília J.
dc.contributor.authorAlencastre, Inês S.
dc.contributor.authorNeto, Estrela
dc.contributor.authorRibas, João
dc.contributor.authorFerreira, Sofia
dc.contributor.authorVasconcelos, Daniel M.
dc.contributor.authorSousa, Daniela M.
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorLamghari, Meriem
dc.date.accessioned2019-05-20T12:49:46Z
dc.date.available2019-05-20T12:49:46Z
dc.date.issued2016
dc.description.abstractBone repair is a specialized type of wound repair controlled by complex multi-factorial events. The nervous system is recognized as one of the key regulators of bone mass, thereby suggesting a role for neuronal pathways in bone homeostasis. However, in the context of bone injury and repair, little is known on the interplay between the nervous system and bone. Here, we addressed the neuropeptide Y (NPY) neuronal arm during the initial stages of bone repair encompassing the inflammatory response and ossification phases in femoral-defect mouse model. Spatial and temporal analysis of transcriptional and protein levels of NPY and its receptors, Y1R and Y2R, reported to be involved in bone homeostasis, was performed in bone, dorsal root ganglia (DRG) and hypothalamus after femoral injury. The results showed that NPY system activity is increased in a time- and space-dependent manner during bone repair. Y1R expression was trigged in both bone and DRG throughout the inflammatory phase, while a Y2R response was restricted to the hypothalamus and at a later stage, during the ossification step. Our results provide new insights into the involvement of NPY neuronal pathways in bone repair.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves, C. J., Alencastre, I. S., Neto, E., Ribas, J., Ferreira, S., Vasconcelos, D. M., Sousa, D. M., Summavielle, T., & Lamghari, M. (2016). Bone Injury and Repair Trigger Central and Peripheral NPY Neuronal Pathways. PLoS ONE, 11(11), e0165465. https://doi.org/10.1371/journal.pone.0165465
dc.identifier.doi10.1371/journal.pone.0165465pt_PT
dc.identifier.other1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.22/13745
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165465pt_PT
dc.subjectAnimalspt_PT
dc.subjectFemurpt_PT
dc.subjectGanglia, Spinalpt_PT
dc.subjectGene Expression Regulationpt_PT
dc.subjectHypothalamuspt_PT
dc.subjectMalept_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred C57BLpt_PT
dc.subjectNeural Pathwayspt_PT
dc.subjectNeuropeptide Ypt_PT
dc.subjectRNA, Messengerpt_PT
dc.subjectReceptors, Neuropeptide Ypt_PT
dc.subjectSignal Transductionpt_PT
dc.subjectWound Healingpt_PT
dc.titleBone injury and repair trigger central and peripheral NPY Neuronal Pathwayspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPagee0165465pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume11pt_PT
person.familyNameAlves
person.familyNameSummavielle
person.givenNameCecília Juliana
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-id3911-5277-41E1
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0002-0719-574X
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id7102051985
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationac966b97-32d2-4022-87d9-36b5a8924d56
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery207ee2de-85a0-4144-9e7e-b376c600e065

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