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Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation

2017Journal article Open access
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dc.contributor.authorAbreu, Ana
dc.contributor.authorCosta, Carla
dc.contributor.authorPinho e Silva, Susana
dc.contributor.authorMorais, Simone
dc.contributor.authorPereira, Maria do Carmo
dc.contributor.authorFernandes, Adília
dc.contributor.authorMoraes de Andrade, Vanessa
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCosta, Solange
dc.date.accessioned2019-05-16T14:41:19Z
dc.date.available2019-05-16T14:41:19Z
dc.date.issued2017
dc.description.abstractPortugal is among the European Union countries most devastated by forest fires each year. In the last three decades, more than 3.8 million hectares of forest were burned. Wildland firefighters are exposed to a variety of hazards, including many toxic combustion products that may lead to deleterious health effects. Epidemiological studies showed a positive association between firefighting and several chronic diseases, including cancer. Results from biomonitoring studies in firefighters, particularly concerning genotoxicity evaluation, constitute a valuable tool for investigating important occupational hazards. Thus, the aim of this study was to assess genotoxicity in a group of wildland firefighters using the comet assay for DNA damage and oxidative stress. Both parameters were increased in firefighters compared to controls, but significance was only found for basal DNA damage. No significant influence was found regarding major confounding variables on the genotoxic endpoints studied, with the exception of age. Data obtained provide preliminary information on human health effects of wildland firefighting exposure at genetic and molecular levels. These findings may also provide new important data to serve as public awareness to the potential adverse health risks involving wildland firefighting. Implementation of security and hygiene measures in this sector as well as good practices campaigns may be crucial to decrease risk.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/15287394.2017.1286896pt_PT
dc.identifier.issn1528-7394
dc.identifier.issn1087-2620
dc.identifier.urihttp://hdl.handle.net/10400.22/13730
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationImpact of transplacental exposure to tobacco smoke in the DNA of newborn. Evaluation of genetic damage and epigenetic changes. Evolution throughout childhood.
dc.relationNew molecular biomarkers for early detection and prevention of frailty in older adults
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/15287394.2017.1286896pt_PT
dc.subjectAdultpt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectComet Assaypt_PT
dc.subjectDNA Damagept_PT
dc.subjectFemalept_PT
dc.subjectFirespt_PT
dc.subjectForestspt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectOccupational Exposurept_PT
dc.subjectOxidative Stresspt_PT
dc.subjectPortugalpt_PT
dc.subjectSmokept_PT
dc.subjectFirefighterspt_PT
dc.titleWood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleImpact of transplacental exposure to tobacco smoke in the DNA of newborn. Evaluation of genetic damage and epigenetic changes. Evolution throughout childhood.
oaire.awardTitleNew molecular biomarkers for early detection and prevention of frailty in older adults
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F96196%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F100948%2F2014/PT
oaire.citation.endPage604pt_PT
oaire.citation.issue13-15pt_PT
oaire.citation.startPage596pt_PT
oaire.citation.titleJournal of Toxicology and Environmental Health, Part A: Current Issuespt_PT
oaire.citation.volume80pt_PT
person.familyNameMorais
person.givenNameSimone
person.identifier1598822
person.identifier.ciencia-idB111-BBFB-F200
person.identifier.orcid0000-0001-6433-5801
person.identifier.scopus-author-id7007053747
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublication86d753c3-265f-4db8-b9dc-a9056b64104f
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