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CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

2018Journal article Open access
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dc.contributor.authorCelestino, Ricardo
dc.contributor.authorNome, Torfinn
dc.contributor.authorPestana, Ana
dc.contributor.authorHoff, Andreas M.
dc.contributor.authorGonçalves, A. Pedro
dc.contributor.authorPereira, Luísa
dc.contributor.authorCavadas, Bruno
dc.contributor.authorEloy, Catarina
dc.contributor.authorBjøro, Trine
dc.contributor.authorSobrinho-Simões, Manuel
dc.contributor.authorSkotheim, Rolf I.
dc.contributor.authorSoares, Paula
dc.date.accessioned2019-05-17T16:34:11Z
dc.date.available2019-05-17T16:34:11Z
dc.date.issued2018
dc.description.abstractBackground: The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. Methods: We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different degree of capsular invasion: two minimally invasive (mFTC) and two widely invasive FTC (wFTC). We searched by genes differentially expressed between mFTC and wFTC, in an attempt to find biomarkers of thyroid cancer diagnosis and/or progression. Selected biomarkers were validated by real-time quantitative PCR in 137 frozen thyroid samples and in an independent dataset (TCGA), evaluating the diagnostic and the prognostic performance of the candidate biomarkers. Results: We identified 17 genes significantly differentially expressed between mFTC and wFTC. C1QL1, LCN2, CRABP1 and CILP were differentially expressed in DTC in comparison with normal thyroid tissues. LCN2 and CRABP1 were also differentially expressed in DTC when compared with follicular thyroid adenoma. Additionally, overexpression of LCN2 and C1QL1 were found to be independent predictors of extrathyroidal extension in DTC. Conclusions: We conclude that the underexpression of CRABP1 and the overexpression of LCN2 may be useful diagnostic biomarkers in thyroid tumours with questionable malignity, and the overexpression of LCN2 and C1QL1 maybe useful for prognostic purposes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCelestino, R., Nome, T., Pestana, A. et al. (2018). CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension. BMC Cancer 18, 68 https://doi.org/10.1186/s12885-017-3948-3
dc.identifier.doi10.1186/s12885-017-3948-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/13732
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://doi.org/10.1186/s12885-017-3948-3pt_PT
dc.subjectAdenocarcinoma, Follicularpt_PT
dc.subjectAgedpt_PT
dc.subjectBiomarkers, Tumorpt_PT
dc.subjectComplement C1qpt_PT
dc.subjectDiagnosis, Differentialpt_PT
dc.subjectHigh-Throughput Nucleotide Sequencingpt_PT
dc.subjectHumanspt_PT
dc.subjectLipocalin-2pt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectNeoplasm Invasivenesspt_PT
dc.subjectPyrophosphatasespt_PT
dc.subjectReceptors, Retinoic Acidpt_PT
dc.subjectTranscriptomept_PT
dc.titleCRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extensionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage68pt_PT
oaire.citation.titleBMC Cancerpt_PT
oaire.citation.volume18pt_PT
person.familyNameCelestino
person.familyNamePestana
person.givenNameRicardo
person.givenNameAna
person.identifier154697
person.identifier.ciencia-id301A-7536-FFE2
person.identifier.ciencia-id0F17-C5B6-D5B5
person.identifier.orcid0000-0002-9605-6433
person.identifier.orcid0000-0003-0200-4059
person.identifier.ridJ-6048-2013
person.identifier.scopus-author-id57195924601
person.identifier.scopus-author-id56404350600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication46a9688a-c1bc-4e3d-a293-86f9b2c03058
relation.isAuthorOfPublication2d366fd2-5e28-4a43-b5f6-4b75bf17d12f
relation.isAuthorOfPublication.latestForDiscovery2d366fd2-5e28-4a43-b5f6-4b75bf17d12f

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