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Antimicrobial activity of quinoxaline 1,4-dioxide with 2- and 3-substituted derivatives

2014Journal article Open access
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dc.contributor.authorVieira, Mónica
dc.contributor.authorPinheiro, Cátia
dc.contributor.authorFernandes, Rúben
dc.contributor.authorNoronha, João Paulo
dc.contributor.authorPrudêncio, Cristina
dc.date.accessioned2019-07-11T13:28:54Z
dc.date.available2019-07-11T13:28:54Z
dc.date.issued2014
dc.description.abstractQuinoxaline is a chemical compound that presents a structure that is similar to quinolone antibiotics. The present work reports the study of the antimicrobial activity of quinoxaline N,N-dioxide and some derivatives against bacterial and yeast strains. The compounds studied were quinoxaline-1,4-dioxide (QNX), 2-methylquinoxaline-1,4-dioxide (2MQNX), 2-methyl-3-benzoylquinoxaline-1,4-dioxide (2M3BenzoylQNX), 2-methyl-3-benzylquinoxaline-1,4-dioxide (2M3BQNX), 2-amino-3-cyanoquinoxaline-1,4-dioxide (2A3CQNX), 3-methyl-2-quinoxalinecarboxamide-1,4-dioxide (3M2QNXC), 2-hydroxyphenazine-N,N-dioxide (2HF) and 3-methyl-N-(2-methylphenyl)quinoxalinecarboxamide-1,4-dioxide (3MN(2MF)QNXC). The prokaryotic strains used were Staphylococcus aureus ATCC 6538, S. aureus ATCC 6538P, S. aureus ATCC 29213, Escherichia coli ATCC 25922, E. coli S3R9, E. coli S3R22, E. coli TEM-1 CTX-M9, E. coli TEM-1, E. coli AmpC Mox-2, E. coli CTX-M2 e E. coli CTX-M9. The Candida albicans ATCC 10231 and Saccharomyces cerevisiae PYCC 4072 were used as eukaryotic strains. For the compounds that presented activity using the disk diffusion method, the minimum inhibitory concentration (MIC) was determined. The alterations of cellular viability were evaluated in a time-course assay. Death curves for bacteria and growth curves for S. cerevisiae PYCC 4072 were also accessed. The results obtained suggest potential new drugs for antimicrobial activity chemotherapy since the MIC's determined present low values and cellular viability tests show the complete elimination of the bacterial strain. Also, the cellular viability tests for the eukaryotic model, S. cerevisiae, indicate low toxicity for the compounds tested.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVieira, M., Pinheiro, C., Fernandes, R., Noronha, J. P., & Prudêncio, C. (2014). Antimicrobial activity of quinoxaline 1,4-dioxide with 2- and 3-substituted derivatives. Microbiological Research, 169(4), 287–293. https://doi.org/10.1016/j.micres.2013.06.015
dc.identifier.doi10.1016/j.micres.2013.06.015pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14336
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0944501313001195?via%3Dihubpt_PT
dc.subjectAnti-Infective Agentspt_PT
dc.subjectCandida albicanspt_PT
dc.subjectEscherichia colipt_PT
dc.subjectMicrobial Sensitivity Testspt_PT
dc.subjectMicrobial Viabilitypt_PT
dc.subjectQuinoxalinespt_PT
dc.subjectSaccharomyces cerevisiaept_PT
dc.subjectStaphylococcus aureuspt_PT
dc.titleAntimicrobial activity of quinoxaline 1,4-dioxide with 2- and 3-substituted derivativespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage293pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage287pt_PT
oaire.citation.titleMicrobiological Researchpt_PT
oaire.citation.volume169pt_PT
person.familyNameVieira
person.familyNameFernandes
person.familyNamePrudêncio
person.givenNameMónica
person.givenNameRúben
person.givenNameCristina
person.identifier635792
person.identifier1200571
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-9614-9031
person.identifier.orcid0000-0001-8933-3984
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridD-8977-2016
person.identifier.scopus-author-id24464652500
person.identifier.scopus-author-id57640135700
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication55587c4b-3df0-4ff1-bade-587420940ecd
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4

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