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Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts

2022Journal article Open access
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dc.contributor.authorGomes, Inês
dc.contributor.authorRodrigues, Helena
dc.contributor.authorRodrigues, Carla
dc.contributor.authorOliveira, Marta Marques
dc.contributor.authorPaíga, Paula
dc.contributor.authorPaiva, Alexandre
dc.contributor.authorSimões, Pedro
dc.contributor.authorFernandes, Virgínia Cruz
dc.contributor.authorVieira, Mónica
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorSoares, Cristina
dc.contributor.authorGrosso, Clara
dc.date.accessioned2023-01-25T15:32:23Z
dc.date.available2023-01-25T15:32:23Z
dc.date.issued2022
dc.description.abstractNeuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content.pt_PT
dc.description.sponsorshipThis work was supported by projects REQUIMTE/LAQV—UIDB/50006/2020 and UIDP/50006/2020, financed by FCT/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), through national funds. A.P. also acknowledges FCT for the project IF/01146/2015, and V.C.F. thanks FCT for the financial support through a postdoctoral fellowship (SFRH/BPD/109153/2015).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/foods11050746pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/21863
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.
dc.relationFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
dc.relation.publisherversionhttps://www.mdpi.com/2304-8158/11/5/746pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectIodinept_PT
dc.subjectMaillard reactionpt_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectNitrosative stresspt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPesticidespt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectSeaweedspt_PT
dc.subjectTotal phenolic contentpt_PT
dc.titleEvaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extractspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.
oaire.awardTitleFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PT
oaire.citation.issue5pt_PT
oaire.citation.startPage746pt_PT
oaire.citation.titleFoodspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamInvestigador FCT
oaire.fundingStreamPOR_NORTE
person.familyNameGomes
person.familyNameMarques de Oliveira
person.familyNamePaíga
person.familyNameFernandes
person.familyNameDelerue-Matos
person.familyNameDias Soares
person.familyNameGrosso
person.givenNameInês
person.givenNameMarta Madalena
person.givenNamePaula
person.givenNameVirgínia
person.givenNameCristina
person.givenNameCristina Maria
person.givenNameAna Clara
person.identifierE-1761-2011
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person.identifier.ciencia-id5016-4F99-C69D
person.identifier.ciencia-id711B-1170-4C32
person.identifier.orcid0000-0002-4288-8496
person.identifier.orcid0000-0003-4150-0151
person.identifier.orcid0000-0002-9593-1355
person.identifier.orcid0000-0003-3979-7523
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0003-0924-9681
person.identifier.orcid0000-0002-2457-8267
person.identifier.ridQ-4930-2018
person.identifier.ridG-4985-2010
person.identifier.ridD-4990-2013
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person.identifier.scopus-author-id57202841330
person.identifier.scopus-author-id6506638953
person.identifier.scopus-author-id37045954500
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id25627935200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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