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Abstract(s)
Alzheimer’s disease (AD) is the most common type of dementia, accounting for 60% to 80% of all cases worldwide. Senile plaques, one of AD hallmarks, are mainly constituted of A peptide. Transthyretin (TTR) has been described to exert a neuroprotective effect in AD by interacting with A. This activity is dependent on its stability, thus compounds that stabilize TTR tetrameric fold increase TTR/A binding. Most of the compounds identified as TTR stabilizers belong to the group of non-steroid anti inflammatory drugs and compete with thyroxine (T4), the natural TTR stabilizer. Investigate the neuroprotective potential of wine polyphenols (Resveratrol, Catechin, Malvidin and Polyphenolic Extract) by exploring their ability to improve TTR/A interaction.
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Citation
Rodrigues, D., Santos, L. M., Alemi, M., Ribeiro, C., Saraiva, M. J., Mateus, N., & Cardoso, I. (2015). Effects of transthyretin stabilization by wine polyphenols in the modulation of Alzheimer’s disease. In R. A. Silva, P. Baylina, F. Q. Vieira, C. Barrias, M. Rubim, T. Coelho, C. Prudêncio, & Â. Jesus (Eds.), II Congresso Internacional da Saúde Gaia Porto: Livro de Resumos (1st ed., Vol. 1, pp. 193). Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto.
Publisher
Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto