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Kinematic biomarkers of functional disability in older adults

2025-09-19Artigo de investigação Acesso aberto
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dc.contributor.authorMoreira, Juliana
dc.contributor.authorCunha, Bruno
dc.contributor.authorFélix, José
dc.contributor.authorSantos, Rubim
dc.contributor.authorSousa, Andreia S. P.
dc.contributor.authorSantos Moreira, Juliana
dc.contributor.authorSousa Félix, José Manuel
dc.contributor.authorRubim Silva Santos, Manuel
dc.contributor.authorPinheiro de Sousa, Andreia Sofia
dc.date.accessioned2026-01-28T11:50:04Z
dc.date.available2026-01-28T11:50:04Z
dc.date.issued2025-09-19
dc.description.abstractThe Timed Up and Go (TUG) test is used to assess mobility in older adults, but its reliance on completion time limits its insight into detailed movement patterns that could serve as early indicators of functional decline. This study aimed to identify lower limb and trunk kinematic biomarkers during the TUG test that distinguish between older adults with and without functional disability, emphasizing the potential for wearable sensor applications. Sixty adults aged 60+ participated in this cross-sectional study. Three-dimensional lower limb and trunk range of motion (ROM), velocity, center of mass (CoM) displacement, and velocity were analyzed using an optoelectronic system across TUG subphases: sitto-walk, walk-forward, turn, walk-back, and turn-to-sit. Principal component analysis identified eleven principal components (PCs), explaining 84.33% of the total variance. PCs included sagittal hip and knee motion and CoM velocity during turn-to-sit and walking (PC1); tri-dimensional trunk velocity during turning, walk-back, and sit-to-walk transitions (PC2, PC4, PC6); sagittal knee and hip velocity in sit-to-walk (PC3); and frontal and transverse plane knee ROM and velocity during turning (PC5). Significant differences between functional disability groups were found for PC1 and PC4. These findings provide benchmark data for developing and validating wearable biosensors aimed at monitoring kinematic biomarkers.eng
dc.identifier.citationMoreira, J., Cunha, B., Félix, J., Santos, R., & Sousa, A. S. P. (2025). Kinematic biomarkers of functional disability in older adults. Biosensors, 15(9), 621. https://doi.org/10.3390/bios15090621
dc.identifier.doi10.3390/bios15090621
dc.identifier.eissn2079-6374
dc.identifier.urihttp://hdl.handle.net/10400.22/31742
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation2020.05356.BD, UIDB/05210/2020
dc.relation.hasversionhttps://www.mdpi.com/2079-6374/15/9/621
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFunctional test
dc.subjectkinematic biomarkers
dc.subjectFactor analysis
dc.subjectAging
dc.subjectBiomechanics
dc.titleKinematic biomarkers of functional disability in older adultseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.titleBiosensors
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSantos Moreira
person.familyNameSousa Félix
person.familyNameRubim Silva Santos
person.familyNamePinheiro de Sousa
person.givenNameJuliana
person.givenNameJosé Manuel
person.givenNameManuel
person.givenNameAndreia Sofia
person.identifier1070119
person.identifier.ciencia-idF217-BF1E-8507
person.identifier.ciencia-id9211-F885-D21C
person.identifier.ciencia-idA018-2B24-C597
person.identifier.ciencia-id2216-9200-7EF6
person.identifier.orcid0000-0003-0123-4960
person.identifier.orcid0000-0003-4498-573X
person.identifier.orcid0000-0002-7394-7604
person.identifier.orcid0000-0001-9528-1463
person.identifier.ridC-7138-2019
person.identifier.scopus-author-id55950021600
relation.isAuthorOfPublication574f928e-bf87-4e65-8396-ae884fa7e544
relation.isAuthorOfPublicationb539fe6f-8318-44ab-b42e-d96f6aa69132
relation.isAuthorOfPublication0a264044-a870-4fca-b976-f7ce003d23a8
relation.isAuthorOfPublicationaeecfe02-e80d-49ab-9033-a1ade15658f2
relation.isAuthorOfPublication.latestForDiscovery574f928e-bf87-4e65-8396-ae884fa7e544

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